The relationship between pregnancy and tumor development hae been investigated by a number of observers, whose multe have been, however, in many instances contradictory. For example, Moreau (1) and Herzog (2) found that transplanted tumors grow with unusual rapidity in pregnant animale. Haaland (3), on the other hand, maintained that pregnsncy exerts a markedly restraining influence on the grow...

We have investigated the role of the Ca(2+)-binding protein S100A9 on tumor growth in prostate cancer and T-cell lymphoma models. We found that the expression of, S100A9 and its interaction with Toll-like receptor 4 (TLR4) is critical for tumor growth in these settings.

the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

Melanoma is a challenging disease to treat. Punica granatum L. has a potential anticancer effect. This study determined the antiproliferative and antiangiogenic potential of the extract from pomegranate peel (PPE) in melanoma. Melanoma cells (1 × 106) were injected to C57BL6 mice subcutaneously. On 8th day, mice were randomly divided into 9 groups. Group 1 was considered as control and received...

the macrophages role within the tumor microenvironment has amended by a variety of factors, thus serves a vital role in tissue morphogenesis. the role of macrophages in health and disease differs enormously as the macrophage has shown dual functions. macrophage has a basic role in antigen presentation serving as the first line of defense in diseases. however the presence of cytokines and growth...

‎‎In this paper‎, ‎the existence and uniqueness of positive solutions for a class of nonlinear initial value problem for a finite fractional difference equation obtained by constructing the upper and lower control functions of nonlinear term without any monotone requirement‎ .‎The solutions of fractional difference equation are the size of tumor in model tumor growth described by the Gompertz f...