T HE multistep theory of tumorigenesis is now widely accepted. During the tumor development the genetic alterations are accumulated, oncogenes are activated, and tumor suppressor genes are inactivated. Recently, the interesting idea is emerging that some cell adhesion molecules, integral membrane proteins, may work as tumor suppressors (Hedrick et al., 1993). Most of these cell adhesion molecul...

ABSTRACT Differential Hox gene expression is central for specification of axial neuronal diversity in the spinal cord. Here, we uncover an additional function proteins developing cord, restricted to B cluster genes. We found that members HoxB are expressed trunk neural tube chicken embryo earlier than from other clusters, with poor antero-posterior specificity and overlapping intermediate zone ...

Abstract The transcription factor E74-like 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role ELF3 bile duct cells by identifying several previously unknown direct target genes that appear to be implicated carcinogenesis. directly repressed ZEB2, key regulator epithelial–mesenchymal transition, and upregulated ex...

Members of the signal transducers and activators of transcription (STATs) family of proteins, which connect cytokine signaling to activation of transcription, are frequently activated in human cancers. Suppressors of cytokine signaling (SOCS) are transcriptional targets of activated STAT proteins that negatively control STAT signaling. SOCS1 expression is silenced in multiple human cancers sugg...

The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects platinum-doped magnesia (Pt/MgO) nanoparticles. chemical compositions, functional groups, size nanoparticles were determined using X-ray diffraction, Fourier transform infrared spectroscopy, energy dispersive transmission electron microscopy, scanning microscopy. Pt/MgO cuboid nanosize range 30–50 ...

Lecithin:retinol acyltransferase-like proteins, also referred to as HRAS-like tumor suppressors, comprise a vertebrate subfamily of papain-like or NlpC/P60 thiol proteases that function as phospholipid-metabolizing enzymes. HRAS-like tumor suppressor 3, a representative member of this group, plays a key role in regulating triglyceride accumulation and energy expenditure in adipocytes and theref...