نتایج جستجو برای: tumor vaccines
تعداد نتایج: 475750 فیلتر نتایج به سال:
Overall, cancer vaccines have had a record of failure as an adjuvant therapy for malignancies that are treated with alkylating chemotherapy, and the contribution of standard treatment to that failure remains unclear. Vaccines aim to harness the proliferative potential of the immune system by expanding a small number of tumor-specific lymphocytes into a large number of antitumor effectors. Clini...
1. Abstract 2. Introduction 3. Stress protein families and their immunological properties 3.1. Chaperoning properties 3.2. Peptide binding properties 3.3. Hsps interact with APCs 4. Immunogenicity of hsps 4.1. Tumor-derived hsp vaccines 4.2. Hsp-peptide based vaccines 4.3. Hsp-protein based vaccines 4.4. Hsp-based DNA vaccines 4.5. Hsp fusion protein vaccines 4.6. Cell-based vaccines 5. Improve...
The development of genetically modified "whole" tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors. In the present study, we have used a disabled infectious single cycle-herpes simplex virus 2 (DISC-HSV-2) vector constructed to express cytokine or marker genes upon infection. DISC-HSV-2 is able to infect a wide range of tumor cells and...
Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine
Suppression of tumor metastasis is a key strategy for successful cancer interventions. Previous studies indicated that rapamycin (sirolimus) may promote tumor regression activity or enhance immune response against tumor targets. However, rapamycin also exhibits immunosuppressant effects and is hence used clinically as an organ transplantation drug. We hypothesized that the immunosuppressive act...
The specificity and potency of the immune system make immunotherapy a potential strategy for the treatment of cancer. To exploit this potential, we have developed cell-based cancer vaccines consisting of tumor cells expressing syngeneic MHC class II and costimulatory molecules. The vaccines mediate tumor regression in mice and activate human CD4+ T cells in vitro. Previous vaccines were generat...
Tumor-specific TCR can serve as an effective target for active immunotherapy of T cell malignancies. Using the murine T cell tumor model C6VL, vaccination with C6VL TCR protected mice from a subsequent lethal dose of tumor cells. This study characterizes the immune mechanisms involved in the tumor protection, and the influence of immunologic adjuvants in inducing a protective immune response. I...
background: the use of dendritic cells (dcs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. it has been demonstrated that listeria mono-cytogenes activated dcs pulsed ex vivo with tumor antigens trigger a systemic th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. objective: the present study w...
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