Introduction: Magnetic fluid hyperthermia (MFH) is a promising therapeutic method in cancer therapy with using magnetic nanoparticles (NPs). In this study, we assessed the effect of MFH on mechanisms of cell death in murine breast cancer cell line (MC4-L2) and also the treatment of breast tumor in BALB/C mice using four generation dendrimer coated iron oxide nanoparticles (G4@I...

Objective(s): Sperm cryopreservation plays an undeniable role in assisted reproductive technology. However, this process significantly reduces the motility, viability, morphology and nuclear integrity of sperm. Reasons of these changes were oxidative stress and apoptosis. The aim of this study was to evaluate the influence of vitamin D on the survival and integrity of ...

AIM To determine the safe dose of intravitreal clonidine (IVC), a potential drug for neuroprotection and angiogenesis inhibition in rabbits. METHODS A total of 28 rabbits were divided into four groups. Three groups received IVC with concentrations of 15 (Group A), 25 (Group B), and 50 (Group C) µg/0.1 mL and the control group (Group D) received 0.1 mL balanced salt solution (BSS). To investig...

BACKGROUND AND PURPOSE Early thrombolytic therapy is encouraged in hyperacute stroke, although this might result in delayed reperfusion injury. Our purpose was to investigate the serial changes in cerebral perfusion following transient ischemia by means of MR imaging and to correlate them with the histologic findings obtained by using the TdT-mediated dUTP-biotin nick-end labeling (TUNEL) assay...

Purpose: To determine the effect of propofol combined with hyperbaric oxygen on spinal cord injury (SCI) in rats.Methods: A total 36 Sprague-Dawley (SD) rats were randomly divided into sham group (S group), model (M and (P group). The Basso, Beattie Bresnahan (BBB) scoring system was adopted to evaluate recovery motor function rats. Subsequently, levels interleukin-18 (IL-18) IL-1β tissues dete...

BACKGROUND This study was conducted to elucidate the effects of raloxifene on proliferation and apoptosis in cultured human uterine leiomyoma cells. METHODS The monolayer cultures were treated with graded concentrations (10(-9), 10(-8) and 10(-7) M) of raloxifene and 10(-7) M 17beta-estradiol (E(2)). Cell viability, percentage of proliferating cell nuclear antigen (PCNA)-positive cells, perce...

Thyroid cancer (TC) is the most prevalent malignant tumor in endocrine system. Serpin peptidase inhibitor clade E member 2 (SERPINE2) closely associated with metastasis. The aim of present study was to investigate whether SERPINE2 forms a feedback loop epidermal growth factor (EGF)/EGF receptor (EGFR) that regulates cellular processes human papillary thyroid carcinoma (TPC‑1) cells. Reverse tra...

BACKGROUND Oxidative stress, inducing cardiomyocyte apoptosis or myocardial ischemia, is the major denominator of many cardiac diseases. In this study, we intended to explore the regulatory function of microRNA-137 (miR-137) in oxidative stress-induced cardiomyocyte apoptosis. MATERIAL AND METHODS Cardiomyocytes were extracted from newborn C57BL/6 mice and cultured in vitro. Apoptosis was ind...

Objective
 The study aimed to evaluate the antioxidant and
 antiapoptotic effects of Resveratrol (RES) against
 Methotrexate (MTX)-induced ovarian damage in
 female rats and were divided into 7 groups:
 Material Method
 Control; MTX (15mg/kg-1st day); (1st 3rd
 (1st, 3rd 5th day) +
 RES (20mg/kg); + RES; MTX
 RES. Since there was only
 one anima...

Abstract Traumatic brain injury (TBI) is a major cause of disabilities and deaths from acute injuries in the US worldwide. Neuroinflammation neuronal apoptosis are hallmarks TBI; however, mechanism clearance apoptotic debris by efferocytosis remains ill-defined. Our previous studies demonstrated that EphA4 receptor peripheral-derived macrophage (PDM) mediates pro-inflammatory response after inj...