purpose: to determine the maximum safe dose for intravitreal injection of anti-ctgf (ivac) in rat eyes in order to decrease gene and protein expression of connective tissue growth factor (ctgf) for the treatment of ocular fibrotic disorders. methods: forty-five lister hooded pigmented rats were divided into one of the five groups of 9 rats; 4 out of these 5 groups received different doses of iv...

BACKGROUND Pelvic fractures, often the result of high energy blunt trauma, are associated with severe morbidity and mortality. A new pelvic stabilizer (T-POD®) provides secure and effective simultaneous circumferential compression of the pelvis. METHODS In this study we describe 15 patients with a prehospital untreated unstable pelvic fracture with signs of hypovolaemic shock with the T-POD®....

The inherent problems associated with inorganic fertilizer such as scarcity and high cost informed the invention of cocoa pod husk based organic fertilizer. The impact of the fertilizer on cocoa output is hereby investigated in this study. The study was conducted in Cross-River State, Nigeria and purposive random sampling technique was used to select fifty cocoa farmers including the user and n...

OBJECTIVES The factors associated with end-of-life (EOL) care that patients with cancer selected and actual place of death (POD) is less elucidated. We analysed how specific EOL care, especially anticancer therapies, selected by patients with pancreatic carcinoma affected their POD in Japan. SETTING A retrospective cohort study using clinical records of a single institute. PARTICIPANTS This...

background and objective: garlic has been known worldwide as a dietary constituent with many pharmacological effects. the present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. material and methods:  human colon adenocarcinoma cells ht29 were treated with different doses (1, 5 and 1...

introduction: cisplatin is an anti-cancer drug used in chemotherapy. one of the limiting side effects of cisplatin is decreasing genital gland function, azoospermia and oligospermia. tribulus terrestris (tt) has been used as an aphrodisiac. the present study amid to investigate the protective effect of tt hydroalcoholic extract against cisplatin-induced apoptisis on testis in mice. methods: mal...

The aim of this study was to examine the effects of angiotensin II (Ang II) on cellular functions of rat podocytes (pod) in the intact freshly isolated glomerulus and in culture. Membrane voltage (Vm) and ion currents of pod were examined with the patch clamp technique in fast whole cell and whole cell nystatin configuration. Vm of pod was -38+/-1 mV (n = 86). Ang II led to a concentration-depe...