Ypt/Rabs are Ras-related GTPases that function as key regulators of intracellular vesicular trafficking. Their slow intrinsic rates of GTP hydrolysis are catalyzed by GTPase-activating proteins (GAPs). Ypt/Rab-GAPs constitute a family of proteins that contain a TBC (Tre-2/Bub2/Cdc16) domain. Only three of the 51 family members predicted in the human genome are confirmed Ypt/Rab-GAPs. Here, we r...

CONTEXT Low back pain (LBP) is a prevalent condition imposing a large socioeconomic burden. Despite intensive research aimed at the efficacy of various therapies for patients with LBP, most evidence has failed to identify a superior treatment approach. One proposed solution to this dilemma is to identify subgroups of patients with LBP and match them with targeted therapies. Among the subgroupin...

STUDY DESIGN Cross-sectional descriptive. OBJECTIVES To investigate if muscle thickness change, as measured with rehabilitative ultrasound imaging (RUSI), is different across subgroups of patients with low back pain (LBP), classified in the Treatment-Based Classification (TBC) system, when compared to controls. BACKGROUND Researchers have demonstrated that subgroups of patients with LBP exi...

The anti-tumor effect of immunization with heat-killed Mycobacterium tuberculosis (Tbc) and Tuberculin (PPD)-coupled syngeneic tumor cells was examined in vivo. Three tumor cell lines were employed. Immunization of Tbc-primed BALB/c mice with PPD-coupled syngeneic Meth-A tumor cells displayed a potent anti-tumor effect on viable Meth-A cells inoculated subcutaneously. Neither PPD-coupled LLC (L...

This study was conducted to determine the efficacy of tulsi (Vitex negundo) leaves, black pepper (Piper nigrum) and cloves (Curcuma longa) extract (TBC extract) as a growth promoter in broilers. A total of 20 day-old broiler chicks were purchased from Nourish Hatchery and after seven days of acclimatization the chicks were randomly divided into two equal groups A and B. No vaccination schedule ...

A novel thermodynamically-balanced inside-out (TBIO) method of primer design was developed and compared with a thermodynamically-balanced conventional (TBC) method of primer design for PCR-based gene synthesis of codon-optimized gene sequences for the human protein kinase B-2 (PKB2; 1494 bp), p70 ribosomal S6 subunit protein kinase-1 (S6K1; 1622 bp) and phosphoinositide-dependent protein kinase...

Mycobacterium tuberculosis infection in patients with cystic fibrosis (CF) is rare. We report a 22-year-old CF patient with high fever, dyspnea and weight loss that progressively worsened over 2 weeks before admission. The patient suffered from liver cirrhosis, was colonized with Pseudomonas aeruginosa and had been repeatedly hospitalized for pulmonary infections. The patient was treated initia...

Abstract Calcium-magnesium-alumino-silicate (CMAS) corrosion is a critical factor which causes the failure of thermal barrier coating (TBC). CMAS attack significantly alters temperature and stress fields in TBC, resulting their delamination or spallation. In this work, evolution process TBC prepared by suspension plasma spraying (SPS) under investigated. The leads to formation reaction layer su...

We converted the Teacher Behaviors Checklist (TBC; Buskist, Sikorski, Buckley, & Saville, 2002) to an evaluative instrument to assess teaching by adding specific instructions and a Likert-type scale. Factor analysis of the modified TBC produced 2 subscales: caring and supportive and professional competency and communication skills. Further psychometric analysis suggested the instrument possesse...