UNLABELLED Grape juice processing by-products, grape seed and pomace are a rich source of procyanidins, compounds that may afford protection against chronic disease. This study was undertaken to identify optimal extrusion conditions to enhance the contents of monomers and dimers at the expense of large molecular weight procyanidin oligomers and polymers in grape seed and pomace. Extrusion varia...

Objective: Hot Melt Extrusion (HME) is one of the techniques for preparing a solid dispersion hydrophilic excipient known as no solvents practical method to increase solubility drugs. Apigenin (APG) has properties that thermal stable with melting point 345-350 °C but very low in water around 1,35 µg/ml. The polymer HME are Soluplus and Kollidon VA 64. study aims optimize kind formulae improve d...