Crossing the midline produces changes in axons such that they are no longer attracted to the midline. In Drosophila, Roundabout reaches high levels on axons once they have crossed the midline, and this prohibits recrossing. Roundabout protein levels are regulated by Commissureless. We show that Commissureless binds to and is regulated by the ubiquitin ligase DNedd4. We further show that the abi...

69 INTRODUCTION The success of operating a drive-thru facility depends on queues and waiting times experienced by customers. Drivethru facilities are required to provide queuing areas that can hold the expected maximum queue length. Rates of arrivals and service times affect the required queuing areas for drive-thru facilities. Gattis recommended queuing areas for drive-thru facilities located ...

Nervous system function requires that neurons within neural circuits are connected together precisely. These connections form during the process of axon guidance whereby each neuron extends an axon that migrates, often large distances, through a complex environment to reach its synaptic target. This task can be simplified by utilising intermediate targets to divide the route into smaller sectio...

In India, 486,476 crashes are reported and 137,572 fatalities during 2013. Major share of crashes (28.8% of total crashes) are on National Highways. Considering high importance of NHs in overall road network with respect to its connectivity to state capitals and business centres, and cater to high share of traffic (40%), there is an urgent need to investigate factors contributing to crashes on ...

Abstract This study evaluates the performance and safety effectiveness of mini-roundabouts. Crash, operational, geometric data for 14 mini-roundabouts located in state Michigan were collected both before after installation time periods between 2007 2016. Three years complete crash analyzed utilizing Before-and-After with Comparison Group methodology. A total 28 untreated sites similar character...

In this paper, we study a two-lane totally asymmetric simple exclusion process (TASEP) coupled with random attachment and detachment of particles (Langmuir kinetics) in both lanes under open boundary conditions. Our model can describe the directed motion of molecular motors, attachment and detachment of motors, and free inter-lane transition of motors between filaments. In this paper, we focus ...

At some intersections, excessive queue lengths may spill out of the left-turn bay and block the through lanes, jeopardizing level of service for the entire intersection. One of the most effective plans recently presented by the researchers is the "Contraflow left-turn lane" (CLL) In this method, left-turn vehicles will use the nearest lane in the opposite direction in addition to the usual left...