Summary Determination of what is the specificity subunits composing a protein complex essential when studying gene variants on human pathophysiology. The pore-forming ?-subunit KCNQ1, which belongs to voltage-gated ion channel superfamily, associates its ?-auxiliary subunit KCNE1 generate slow cardiac potassium IKs current, whose dysfunction leads arrhythmia. Using pharmacol...

The LmbE-like superfamily is comprised of a series of enzymes that use a single catalytic metal ion to catalyze the hydrolysis of various substrates. These substrates are often key metabolites for eukaryotes and prokaryotes, which makes the LmbE-like enzymes important targets for drug development. Herein we review the structure and function of the LmbE-like proteins identified to date. While th...

A list of 1,673 specimens bats belonging to 36 species, seven genera, and five families the superfamily Rhinolophoidea, housed in collection National Museum, Prague, Czech Republic, is presented a systematic review.