Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. Here we determine the genetic variation within the human TLR4 gene encoding the principal receptor for bacterial endotoxin recognition in typhoid fever patients. It is possible that genetic variants of TLR4 could detrimen...

Salmonella enterica serotype typhi is the aetiological agent of typhoid fever, a multisystemic disease with protean manifestations and initial lesions in the bowel. Typhoid fever still remains a major public health problem in developing countries even in the twenty first century (Lin et al., 2000; Otegbayo et al., 2003). This was also the case in America and Europe three centuries ago, until me...

DR. AGNES C. VIETOR.Mr. President, I have been very much interested in the discussion on typhoid and paratyphoid fever, particularly because I have, in common with other practitioners, had cases of typhoid fever, clinical typhoid, that did not give the laboratory reaction. In reading a number of articles on this subject, within recent times, I was impressed with the resemblance of the problem t...

OBJECTIVE To determine the clinical manifestations and outcomes, the reliability of Salmonella enterica serotype Typhi (S ser. Typhi) IgM and IgG rapid tests, and the susceptibility patterns and the response to treatment during the 2009-2011 typhoid outbreak in Songkhla province in Thailand. METHOD The medical records of children aged <15 years with S ser. Typhi bacteremia were analysed. The ...

Vaccines against Salmonella Typhi, the causative agent of typhoid fever, are commonly used by travellers, however, there are few examples of national immunization programs in endemic areas. There is therefore a paucity of data on the impact of typhoid immunization programs on localised populations of S. Typhi. Here we have used whole genome sequencing (WGS) to characterise 44 historical bacteri...

INTRODUCTION Although typhoid fever is confirmed by culture of Salmonella Typhi, Widal test is widely used in India but little information exists about its reliability. MATERIALS AND METHODS We examined the performance of Widal test in our hospital for diagnosis of typhoid fever in children. Hundred consecutive pediatric in-patients for whom, the Widal test was requested were grouped into fou...

Since Vi antigen is limited primarily to Salmonella typhi, it has been thought that detection of the antigen may be a useful method for diagnosing acute typhoid fever. The slide coagglutination method and enzyme-linked immunosorbent assay have recently been suggested as ways to detect small quantities of Vi antigen in urine. In Santiago, Chile, we compared the results of these two methods in pa...

Typhoid is a global problem. Conventional diagnostic methods have limitations. The Widal test gives a high proportion of false positive results, and indiscriminate use of antibiotics has reduced the utility of blood culture. Consequently, these procedures are inadequate for diagnosing suspected cases of typhoid that do not present clear-cut symptoms. We previously showed that PCR-based diagnosi...

OBJECTIVES To determine the seropositivity of typhoid fever in febrile pediatric patients presenting to tertiary care center. METHODS This observational study was conducted at Children Hospital Quetta (CHQ) from July 2011 to March 2012. The children with three or more days fever, no obvious focus of infection and clinically suspected of typhoid fever were screened. Sterile Blood samples were ...