The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a 'driver' of UCC, we targeted the expression of mutated Fgfr3 to the murine urothelium using Cre-loxP recombination driven by the uroplakin II promoter. The introduction of the Fgfr3 mutations resul...

This study examines Pennsylvanian shales in Indiana as a potential source of selected critical elements: rare earth elements (REE), vanadium (V), zinc (Zn), arsenic (As), and cadmium (Cd). Widespread, organic-matter-rich marine Desmoinesian black are the main target, but other discontinuous shale horizons were also sampled 11 locations. In total, 39 samples analyzed this study. The early mature...

In many treatment systems, adolescents referred to residential treatment have the most serious alcohol or other substance use disorders and are at high risk of relapse. Upon discharge, these adolescents are typically referred to continuing care services, however, linkage to these services is often problematic. In this study, 114 adolescents (76% male) who stayed at least 7 days in residential t...

RECQ helicases are a family of enzymes with both over lapping and unique functions. Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5. Here we demons...

Urothelial cell carcinoma (UCC) metastases to skeletal muscle are extremely rare and usually found in patients with advanced stage cancer. The most common sites of bladder cancer metastases are lymph nodes, lung, liver, and bones. Muscle is an unusual site of metastases from a distant primary cancer, due to several protective factors. We present a rare case of 76-year-old patient with metastase...

ABSTRACT The umbilical cord constriction (UCC) is an uncommon condition and important etiology for stillborn fetuses. main goal of this study was to verify the UCC occurrence as cause intrauterine fetal death, associated its pathological characteristics. Therefore, a descriptive retrospective cross-sectional developed using database from Pathology Institute, in Brazil, 1995 2017. results presen...

Many people from all over the world have been supplied with mobile terminals, which has increased the computing power of each individual. Based on this increased utilization of mobile terminals, there are new services that are emerging. Also, as user created content (UCC) is becoming widely available, the new era of easily sharing contents with others has started. Also, users prefer realtime UC...

We test the hypothesis that the opening of an Urgent Care Center (UCC) has positive impacts on the local community. There are several mechanisms through which a UCC can have an impact: lower health care costs, emergency room decongestion, and improved access to medical information. We examine the entry of MedExpress into Appalachian counties between 2001 and 2013. Employing data from Health Res...

The aims of this study were to examine perceptions of what a sample of students and graduates consider an excessive alcohol intake to be and it's effect on their health. 115 University College Cork (UCC) students and 133 UCC graduates were questioned about their opinions of an acceptable weekly intake of alcohol. The results reveal dramatic changes in drinking habits over recent decades. Studen...