نتایج جستجو برای: ulcerative atherosclerotic plaque
تعداد نتایج: 70932 فیلتر نتایج به سال:
In MI there is a decrease in coronary flow or an equivalent abrupt increase in myocardial demand for oxygen due to ischemic necrosis caused by obstruction in the coronary artery. Thrombus or atherosclerotic plaque may obstruct the coronary flow. The atherosclerotic lesion contain macrophage and activated T-cells which secrete cytokines . This inflammatory response results in plaque rupture and ...
Formation of atherosclerotic and calcified plaque begins and grows up not only beneath the endothelium (intimae), but also in the adventitial subepithelium on the coronary arteries. A new innovative combined drug (polypill) is certainly releases, regress and prevents of formation of the atherosclerotic and calcified plaque of arteries.
BACKGROUND Atherosclerosis is a leading cause of mortality in the Western world, and plaque diagnosis is still a challenge in cardiovascular medicine. The main focus of this study was to make atherosclerotic plaques visible using targeted nanoparticles for improved imaging. Today various biomarkers are known to be involved in the pathophysiologic scenario of atherosclerotic plaques. One promisi...
BACKGROUND Imaging modalities to assess atherosclerotic plaque thrombogenicity have not been established, so in this study the relationship between [(18)F]-fluorodeoxyglucose ((18)F-FDG) uptake and thrombus formation was investigated in rabbit atherosclerotic arteries. METHODS AND RESULTS Atherosclerotic plaque was induced in the iliacofemoral artery by balloon injury and a 0.5% cholesterol d...
conclusions a significant proportion of coronary atherosclerotic plaques in cadavers with confirmed acute myocardial infarction were detected to be infected with cytomegaloviruses while no infections of c. pneumoniae and h. pylori were detected. patients and methods sixty cadavers in two equal groups were analyzed. acute myocardial infarction group included cadavers with acute myocardial infarc...
Apoptosis of macrophages and vascular smooth muscle cells (VSMCs) in advanced atherosclerotic plaques contributes to plaque progression and instability. Caspase-3, a key executioner protease in the apoptotic pathway, has been identified in human and mouse atherosclerotic plaques but its role in atherogenesis is not fully explored. We therefore investigated the impact of caspase-3 deletion on at...
Arterial thrombosis occurs at sites of erosion or rupture of atherosclerotic vascular lesions. To better study the pathophysiology of this complex phenomenon, there is a need for animal models of localised thrombosis at sites of atherosclerotic lesions with closer resemblance to the human pathology as compared to commonly used thrombosis models in healthy vessels. In the present study, we descr...
RATIONALE AND OBJECTIVE Membrane-shed submicron microparticles (MPs) released following cell activation or apoptosis accumulate in atherosclerotic plaques, where they stimulate endothelial proliferation and neovessel formation. The aim of the study was to assess whether or not MPs isolated from human atherosclerotic plaques contribute to increased endothelial adhesion molecules expression and m...
-Retrospectively, plaque rupture is often colocalized with inflammation of the cap and shoulder of the atherosclerotic plaque. Local inflammation is therefore considered a potential marker for plaque vulnerability. However, high specificity of inflammation for plaque rupture is a requisite for application of inflammation markers to detect rupture-prone lesions. The objective of the present stud...
BACKGROUND Atherosclerosis is a complex disease requiring improvements in diagnostic techniques and therapeutic treatments. Both improvements will be facilitated by greater exploration of the biology of atherosclerotic plaque. To this end, we carried out large-scale gene expression analysis of human atherosclerotic lesions. METHODS AND RESULTS Whole genome expression analysis of 101 plaques f...
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