Abstract Background : To investigate the associations of serum vitamin D and Fok I polymorphism its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA). Methods Ninety URSA patients another 104 healthy pregnant women were selected as control groups, respectively. 25-Hydroxyvitamin [25-(OH)D] level was detected by chemiluminescence. VDR gene analyzed PCR, distribution genotype ...

Background: The aim of this study was to examine the possible relationship between sperm DNA integrity and chromatin packaging evaluated by cytochemical assays, traditional sperm parameters and recurrent spontaneous abortion (RSA) of unknown origin. Materials and Methods: In this cohort study, 40 couples with a history of RSA and 40 couples with proven fertility were considered as case and cont...

BACKGROUND Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. OBJECTIVE The objectives of this study were to search if these sera could induce DNA denaturation in sperm nucle...

Background: Recurrent abortion is defined as 3 or more pregnancy loses. It is estimated that between 0/5 to 3 percent of couples suffer from recurrent abortion. The male gamete contributes 50% of genomic Materials to the embryo and contributes as well as to placental and embryonic development. Oral antioxidant treatment has been reported to reduce the percentage of damaged spermatozoa and impro...

We read with great interest the article by Bates et al 1 in an issue of CHEST (February 2012), in which the authors evaluate the evidence on the risk of pregnancy complications in women with thrombophilia. In this guideline article, the authors recommend screen ing for antiphospholipid antibodies in women with recurrent early pregnancy loss with a high level of evidence (Grade 1B). The antiphos...

introduction: robertsonian translocation is one of the major chromosomal rearrangements with a prevalence rate of 0.1% of the general population and 1% of the infertile population. in this report, we present a nonhomologous robertsonian translocation in a female patient with a history of repeated abortions. case presentation: a couple with the complaint of repeated abortions was admitted in the...