sustained release oral delivery systems are designed to achieve therapeutically effective concentrations of drug in the systemic circulation over an extended period of time. the purpose of the present investigation was to design and evaluate sustained release matrix tablets of nifedipine, a poorly water soluble drug, employing hydroxypropyl methyl cellulose ( hpmc) and ethyl cellulose ( ec) as ...

The radon chamber at Bowser-Morner was designed to ensure that the concentration of radon throughout the chamber is uniform. Nevertheless, it is important to demonstrate this uniformity periodically with measurements. To that end, 36 continuous radon monitors were simultaneously deployed in the chamber in a statistically balanced pattern and were exposed for a period of 48 hours. The resulting ...

Let Z denote a finite collection of reduced points in projective n-space and let I denote the homogeneous ideal of Z . The points in Z are said to be in (i, j)-uniform position if every cardinality i subset of Z imposes the same number of conditions on forms of degree j . The points are in uniform position if they are in (i, j)-uniform position for all values of i and j . We present a symbolic ...

Let Z denote a finite collection of points in projective n-space and let I denote the homogeneous ideal of Z. The points in Z are said to be in (i, j)-uniform position if every cardinality i subset of Z imposes the same number of conditions on forms of degree j. The points are in uniform position if they are in (i, j)-uniform position for all values of i and j. We present a symbolic algorithm t...

With new technologies such as machine-to-machine communications there is a growing need to test large-form-factor devices in reverberation chambers. The performance of the reverberation chamber can be affected by the physical characteristics of these devices. In this report it is discussed how the spatial uniformity of the received stirred power and the received total power (stirred + unstirred...

Manometry is a noninvasive diagnostic tool for identifying motility dysfunction of the gastrointestinal tract. Despite the great technical advances in monitoring motility, performance of the study in pediatric patients has several limitations that should be considered during the procedure and interpretation of the test results. This article reviews the clinical applications of conventional esop...

A general goodness-of-fit test for scale-parameter families of distribu­ tions is introduced, which is based on quotients of expected sample minima. The test is independent of the mean of the distribution, and, in applications to testing for expQnentiality of data, compares favorably to other goodness-of-fit tests for expo­ nentialitybased on the empirical distribution function, regression meth...

Abstract Assessing goodness of fit to a given distribution plays an important role in computational statistics. The probability integral transformation (PIT) can be used convert the question whether sample originates from reference into problem testing for uniformity. We present new simulation- and optimization-based methods obtain simultaneous confidence bands whole empirical cumulative functi...