In the title compound, C(12)H(16)N(2)OS, an intra-molecular N-H⋯O hydrogen bond forms an S(6) ring motif. The propionyl-thio-urea group is approximately planar [with a maximum deviation of 0.135 (2) Å] and forms a dihedral angle of 83.39 (7)° with the benzene ring. In the crystal, mol-ecules are linked by pairs of N-H⋯S hydrogen bonds, forming centrosymmetric dimers and generating R(2) (2)(8) r...

The asymmetric unit of the title cyclic thio-urea derivative, C10H12N2S, comprises two mol-ecules, each of which has a twist about the CH2-CH2 bond within the five-membered ring. The major difference between the independent mol-ecules is manifested in the relative orientations of the five- and six-membered rings [dihedral angles between the least-squares planes = 28.03 (11) and 41.54 (11)°]. A ...

In the title compound, C10H19N3S, the cyclo-hexyl group adopts a chair conformation and adopts a position approximately syn to the thione S atom. The CN2S thio-urea moiety makes dihedral angle of 13.13 (10)° with the propan-2-yl-idene-amino group. An intra-molecular N-H⋯N hydrogen bond is noted. In the crystal, inversion dimers linked by pairs of N-H⋯S hydrogen bonds generate R (2) 2(8) loops.

Various methods have been used by different investigators t.o estimate the stability of amide to amide hydrogen bonds in aqueous solution. Schellman (1) and Kauzmann (2) have discussed the thermodynamic properties of t)he C=O--HN bond in water wit,h the use of aqueous urea solutions as a model system. From studies on heats of dilution of urea in water, Schellman concluded that this bond has an ...

The title compound, C(13)H(10)ClN(3)OS, was prepared by the reaction of 3-amino-2-chloropyridine with benzoyl isothio-cyanate at room temperature. The thio-urea group makes dihedral angles of 47.17 (5) and 51.88 (4)°, respectively, with the benzene and pyridyl rings, while the angle between the benzene and pyridine rings is 8.91 (3)°. Inter-molecular hydrogen-bond inter-actions link neighbourin...

The title compound, C(17)H(18)N(2)OS, adopts a trans-cis geometry of the thio-urea group which is stabilized by intra-molecular hydrogen bonds between the O atom of the carbonyl group and the H atom of the thio-amide group. A C-H⋯S intramolecular hydrogen bond is also present. In the crystal structure, mol-ecules are linked by inter-molecular N-H⋯S hydrogen bonds to form centrosymmetric dimers.

The reaction of propionyl isothio-cyanate with valine was found to give the title compound, C(8)H(15)NO(3), instead of the expected thio-urea product. The whole mol-ecule is non-planar and the carbonyl group is cis to the methyl-butanoic acid group across the C-N bond. Inter-molecular O-H⋯O and N-H⋯O hydrogen bonds build up a two-dimensional network developing parallel to (100).

The phenylurea moiety is a ubiquitous synthon in supramolecular chemistry. Here we report that the introduction of chlorine or bromine atoms in the ortho positions to the urea unit is a simple and very efficient way to improve its intermolecular hydrogen bond (HB) donor character. This effect was demonstrated in solution both in the context of self-association of bis-ureas and hydrogen bonding ...

The title compound, C(16)H(20)F(3)N(3)O(4), was prepared by reaction of 4-(dimethyl-amino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxo-butanoate and urea. In the title mol-ecule, the pyrimidine ring adopts a half-chair conformation and there is an intra-molecular hydrogen bond (O-H⋯O). The crystal structure is stabilized by two types inter-molecular hydrogen bonds (N-H⋯O and N-H⋯N).

There are four independent mol-ecules in the asymmetric unit of the title compound, C(11)H(15)N(3)S(2), with different conformations: the dihedral angles between the benzene rings and thio-urea units are 16.85 (9), 0.56 (10), 8.05 (12) and 4.56 (8)°. Each mol-ecule contains an intra-molecular N-H⋯N hydrogen bond, generating an S(5) ring. The crystal structure is stabilized by inter-molecular N-...