Lysosomal membrane permeabilization (LMP) has been shown to cause the release of cathepsins and other hydrolases from the lysosomal lumen to the cytosol and initiate a cell death pathway. Whether proteinuria triggers LMP in renal tubular epithelial cells (TECs) to accelerate the progression of renal tubulointerstitial injury remains unclear. In the present study, we evaluated TEC injury as well...

Diabetic nephropathy (DN) is one of the major causes of end stage renal disease. Angiotensin converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) are preferred for delaying progression of DN. This study compared the preventive renal effects of telmisartan (10 mg/kg, p.o.), an ARB that completely blocks angiotensin action, and benazepril (5 mg/kg, p.o.), an ACE inhibitor, whi...

Urinary tract infection is most frequently found bacterial in urinary of human beings and 75-95% infections are caused by uropathogenic . The bacteria produces several virulence factors, siderophore one them. Siderophore iron acquisition protein play significant role pathogenicity UTI’s helping to persist host cells adverse conditions. study was conducted at SRL laboratory Ujjain Center from No...

The objectives of this work were to examine the association between urinary protein and blood pressure and to compare the pattern of urinary protein excretion with essential hypertension in people of European origin (whites) and in people of African or African-Caribbean origin (blacks) living in southwest London, United Kingdom. In the groups as a whole, there were no significant differences in...

background: early detection of renal diseases in children can be beneficial for prevention, delaying disease progression, reduction of the number of patients with progressive renal failure. the most common metabolic disorders predisposing renal calculus in children are: hypercalciuria, hyperuricosuria, hyperoxaluria, renal tubular acidosis, and hypocitraturia. objectives: in this research, we s...

The possibility that hyperlipidemia and an increase of mononuclear cells in the glomeruli could participate in the pathogenesis of minimal change glomerulopathy was evaluated in puromycin aminonucleoside (PAN) nephrosis in rats. Significant increases in intraglomerular CD4-, IL-2-receptor (R)- and ED-1-positive cells were found in PAN rats. Urinary protein excretion and mononuclear cells in the...

AIM The study assessed mRNA expression of podocyte-associated molecules in urinary sediments of patients with type 2 diabetes mellitus (DM) in relation to urinary podocytes, biomarkers of podocyte injury and of proximal tubule (PT) dysfunction. METHODS A total of 76 patients with type 2 DM and 20 healthy subjects were enrolled in a cross-sectional study, and assessed concerning urinary podocy...

screening interval urinalysis has long been considered essential to pediatric health care. a urinalysis is recommended at four times: in infancy, early childhood, late childhood, and in adolescence. several chemical parameters can be measured as commercially available in dipstick test. this test is relatively inexpensive and it takes less than 5 minutes to be completed. in a 3 month follow up p...

BACKGROUND Diabetic nephropathy is the major cause for chronic renal failure (CRF) and proteinuria is an independent risk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of prime importance in the diagnosis and management. METHODS This study was conducted amongst 42 diabetic subjects from HSK hospital, Bagalkot. Twenty four-hour urine prote...

BACKGROUND Transforming growth factor-beta1 (TGF-beta1) is the major profibrotic cytokine involved in many renal diseases, and urinary TGF-beta1 reflects intrarenal TGF-beta1 production. Urinary TGF-beta1 excretion is reported to be significantly increased in patients with immunoglobulin A (IgA) nephropathy. The aim of the present study was to compare the effects of losartan and amlodipine on p...