The activity of CD101 and comparator antifungal agents against 606 invasive fungal isolates collected worldwide during 2014 was evaluated using the Clinical and Laboratory Standards Institute (CLSI) method. All Candida albicans (n = 251), Candida tropicalis (n = 51), Candida krusei (n = 16), and Candida dubliniensis (n = 11) isolates were inhibited by ≤0.12 μg/ml of CD101 and were susceptible o...

DOS Times Vol. 12, No. 9 March, 2007 Endophthalmitis is one of the most vision threatening complication in Ophthalmology. Endophthalmitis refers to inflammatory response caused by infected intraocular tissues/ fluids. The frequency of Endophthalmitis after cataract surgery and trauma varies from 0.07 0.13% and 2.417% respectively in the various reported series.1 Majority of these infections are...

The phylogenetic relationships of the most dominant and morphologically cryptic endophytic fungal isolates from each of five selected medicinal plants, namely Potentilla fulgens, Osbeckia stellata, Osbeckia chinensis, Camellia caduca, and Schima khasiana of the biodiversity rich state of Meghalaya, were assessed with random amplification of polymorphic DNA and PCR-restriction fragment length po...

Xerophilic fungal species of the genus Aspergillus are economically highly relevant due to their ability to grow on low water activity substrates causing spoilage of stored goods and animal feeds. These fungi can synthesize a variety of secondary metabolites, many of which show animal toxicity, creating a health risk for food production animals and to humans as final consumers, respectively. An...

Phytate is the primary storage form of phosphate in plants. Monogastric animals like poultry, pigs and fishes have very low or no phytase activities in their digestive tracts therefore, are incapable to efficiently utilize phytate phosphorus from the feed. Phytase from microbial sources are supplemented to feedstuff of these to increase the uptake of phytate phosphorus. In the present work effo...

Objective: The genus Trichoderma comprises a great number of fungal strains that act as biological control agents, the antagonistic properties of which are based on the activation of multiple mechanisms. Methods: Trichoderma strains exert biocontrol against fungal phytopathogens either indirectly, by competing for nutrients and space, modifying the environmental conditions, or promotin...

in this investigation the effect of trichoderma isolates in inhibition of aspergillus flavus growth and reducing of aflatoxin b1 (afb1) was studied in culture media and pistachio nuts. among trichoderma isolates, t1, t3, t4 and t17 isolates showed significant impact on inhibiting of a. flavus r5growth. t3 and t4 isolates were the most effective isolates, which caused 84.40% and 77.88% reduction...

OBJECTIVES Despite the need for novel drugs to combat fungal infections, antifungal drug discovery is currently limited by both the availability of suitable drug targets and assays to screen corresponding targets. The aim of this study was to screen a library of small chemical compounds to identify cell wall inhibitors using a conditional protein kinase C (PKC)-expressing strain of Aspergillus ...

Candida being a major blood stream fungal pathogen, risk stratification in patients and correct identification of species is the need of the hour owing to emergence of nonC. albicans and antifungal resistance. We aimed to speciate Candida isolates from blood cultures, evaluate anti-fungal susceptibility pattern and assess risk factors in this retrospective cohort study between May 2013 to Decem...

Diverse fungal species live on the surfaces of plant tissues, some of which presumably occur in a mutualistic association. Some fungal species are widespread and can be found in many different animal species, whereas others are highly specific to single hosts. In this study, we investigated the taxonomic identities and phylogenetic relationships of fungal species isolated from tree shrew hair s...