Introduction: Leiomyoma are benign mesenchymal tumors presenting as the most common uterine neoplasm. Atypical leiomyoma (ALM), a nomenclature given in WHO classification, is a leiomyoma variant showing histopathological features ranging between a benign leiomyoma and leiomyosarcoma (LMS). It is a rare smooth muscle neoplasm detected mostly on histological examination in myomectomy and hysterec...

"Benign metastasizing leiomyoma" is the terminology used to describe a controversial entity characterized by a proliferation of bland-appearing smooth muscle in lung or abdominopelvic lymph nodes. In this report, we describe 5 cases of pulmonary-based smooth muscle tumors that are clinically and histologically consistent with this entity, and in which we identified consistent chromosomal aberra...

BACKGROUND Cotyledonoid dissecting leiomyoma is a rare variant of uterine smooth muscle tumor with an unusual growth pattern that shows intramural dissection within uterine myometrium and often a placenta-like appearance in its extrauterine components. CASE PRESENTATION We present a unique case of cotyledonoid dissecting leiomyoma with adenomyosis. A 40-year-old Japanese female presented with...

Background and objective Uterine leiomyoma is the most common benign tumor in females of reproductive age. However, its causes have never been fully understood. The our study was to analyze causal association between various factors uterine using Mendelian randomization (MR). Methods Genetic variables associated with risk were obtained from genome-wide studies. Summary-level statistical data fo...

Pulmonary benign metastasizing leiomyoma (BML) is a rare disease occurring predominantly in women of reproductive age and usually develops several years after the resection of a uterine leiomyoma. A 52-year-old postmenopausal woman was admitted to our hospital because of a right-sided empyema. Contrast-enhanced computed tomography showed a multiloculated pleural effusion on the right side and m...

Objective To report the management of a large uterine leiomyoma with diffuse cystic degeneration in a patient with autosomal dominant polycystic kidney disease (ADPKD). Design Case Report. Setting Cleveland Clinic Florida, Department of Gynecology, Section of Minimally Invasive Gynecologic surgery, Weston Florida. Patients A 52-year old woman with ADPKD with a large abdominal mass, abnorm...

Uterine leiomyomas are one of the most common benign gynecologic tumors, but the exact causes are not completely understood. In 2011, through DNA sequencing, MED12 mutation was discovered in approximately 71% of uterine leiomyomas. Several recent studies confirmed the high frequency of MED12 mutation in uterine leiomyoma. Nevertheless, no study has been done on MED12 mutation in the case of pat...

We recently found that aberrant DNA hypomethylation is more common on the X chromosome than on other chromosomes in uterine leiomyomas by genome-wide DNA methylation profiling. To investigate the mechanism of aberrant hypomethylation on the X chromosome in uterine leiomyomas, we analyzed methylome and transcriptome data from three cases of leiomyomas and the adjacent myometrium. We found that e...

T of a gravid uterus is rare, but torsion of a non-gravid uterus is rarer.1 The leading cause of torsion of a non-gravid uterus is leiomyoma. Magnetic resonance imaging (MRI) could be helpful in the diagnosis of torsion in some cases.2 We report a case of uterine torsion in which an anterior leiomyoma mimicked a broad ligament leiomyoma on imaging studies. A 36-year-old woman was referred to ou...