We present a lattice gas cellular automaton (LGCA) to study spatial and temporal dynamics of an epidemic of SIR (susceptible-infected-removed) type. The automaton is fully discrete, i.e. space, time and number of individuals are discrete variables. The automaton can be applied to study spread of epidemics in both human and animal populations. We investigate effects of spatial inhomogeneities in...

Enhanced disease is the term used to describe the aberrant Th2-skewed responses to naturally acquired human respiratory syncytial virus (hRSV) infection observed in individuals vaccinated with formalin-inactivated viral Ags. Here we explore this paradigm with pneumonia virus of mice (PVM), a pathogen that faithfully reproduces features of severe hRSV infection in a rodent host. We demonstrate t...

A Markovian susceptible --> infectious --> removed (SIR) epidemic model is considered in a community partitioned into households. A vaccination strategy, which is implemented during the early stages of the disease following the detection of infected individuals is proposed. In this strategy, the detection occurs while an individual is infectious and other susceptible household members are vacci...

The presence of poliovirus (PV)-specific CD4(+) T cells in individuals vaccinated against polio has been shown, but CD8(+) T-cell responses have not been described. Here, we functionally characterize the CD4(+) T-cell response and show for the first time that dendritic cells and macrophages can stimulate PV-specific CD8(+) T-cell responses in vitro from vaccinees. Both CD4(+) T and CD8(+) T cel...

Abstract. The Simple Epidemic Model uses three states to describe the spread of an infection: the susceptible (S), the infected (I), and the recovered (R). This model follows the trend of an infection over time and can predict whether an infection will spread. Using this model, epidemiologists may calculate the percentage of the population that needs to be vaccinated in order to provide a popul...

A strain of Mycobacterium bovis BCG that secretes high levels of functional murine monocyte chemotactic protein 3 (BCG(MCP-3)) was developed. Mice vaccinated with BCG(MCP-3) displayed increased lymphocyte migration in vivo and augmented antigen-specific T-cell responses compared to mice vaccinated with BCG alone. The level of protection afforded by BCG(MCP-3) was equivalent to that with control...

Background. Tetanus is an acute disease caused by a neurotoxin produced by Clostridium tetani. Tetanus immunization has been available since the late 1930s but sporadic cases still occur, usually in incompletely vaccinated or unvaccinated individuals. Case Report. An elderly previously vaccinated female contracted tetanus following foot injury. Clinically she presented with meningitis causing d...

We propose a method to analyse the 2009 outbreak in the region of Botucatu in the state of São Paulo (SP), Brazil, when 28 yellow fever (YF) cases were confirmed, including 11 deaths. At the time of the outbreak, the Secretary of Health of the State of São Paulo vaccinated one million people, causing the death of five individuals, an unprecedented number of YF vaccine-induced fatalities. We app...

To the editor: Low rates of vaccine uptake have been observed during the national immunisation campaign against the 2009 pandemic influenza A(H1N1) in Greece. Data from the national influenza A(H1N1) immunisation programme that started on 16 November 2009 in Greece reveal that as of 8 January 2010 approximately 360,000 persons have been vaccinated (3.2% of the population). Of these approximatel...

In this paper, we study the spreading of epidemic in a network individuals who may either contract disease through contact with infected nearest neighbors or be vaccinated under influence are already vaccinated. We show that both interaction between susceptible S and I imitation vaccination, form sociological V individuals, lead to phase transition. If is supercritical condition, corresponding ...