OBJECTIVE Our purpose was to compare the safety and efficacy of intravaginal misoprostol versus intracervical prostaglandin E2 gel (dinoprostone) for preinduction cervical ripening and induction of labor. STUDY DESIGN Two hundred seventy-six patients with indications for induction of labor and unfavorable cervices were randomly assigned to receive either intravaginal misoprostol or intracervi...

background: difficulty in cervical dilatation is a hard situation during the procedure of diagnostic dilatation and curettage in some cases. this study was performed to evaluate the effect of vaginal misoprostol for cervical priming before diagnostic dilatation and curettage. methods: in this study 56 women were selected as the candidates for dilatation and curettage. the study was double blind...

STUDY QUESTION Can sublingual administration of misoprostol 1 h prior to vacuum aspiration be more effective than vaginal administration and as effective as either route three 3 h prior to surgery? SUMMARY ANSWER Sublingually administered misoprostol is superior to vaginally administered misoprostol when given 1 h pre operatively, and it is as effective as after a three 3 h priming interval w...

BACKGROUND To evaluate the effects of vaginal misoprostol on cervical dilatation before operative hysteroscopy in pre-menopausal women. METHODS Four groups of 12 women were randomly assigned to receive either placebo or vaginal misoprostol in doses of 200, 400 or 800 micro g 4 h before the surgical procedure. The number of patients was calculated with an alpha = 0.01 and beta =0.20 for a diff...

OBJECTIVE To compare the effectiveness of titrated orally and vaginally administered misoprostol for induction of labour. STUDY DESIGN Unmasked randomized controlled trial. SETTING Department of Obstetrics and Gynaecology University of Zimbabwe, Harare. SUBJECTS Pregnant women with singleton foetus in cephalic presentation booked for induction of labour, were randomized to receive titrate...

Various methods of induction of labour may be associated with risk and complications. Therefore, this study has been undertaken to compare the safety and efficacy of intra-vaginal misoprostol (PGE1 analogue) with intra-cervical dinoprostone (PGE2) in progress and induction of labour, the maternal side effects and the foetal outcome. 40 pregnant women aged between 16-35 years with indication of ...

OBJECTIVE To identify an effective misoprostol-only regimen for termination of pregnancy between 12 and 20 weeks of gestation, a prospective randomized study comparing sublingual, vaginal, and oral routes of administration of misoprostol was done. METHODS One hundred and fifty women (12-20 weeks gestation) were randomly divided into three groups and given 400 mcg misoprostol sublingually, vag...

Intrauterine devices (IUD) are a highly effective and safe form of contraception. However, many individuals, particularly nulligravidas, elect against IUD use due to fear of pain associated with insertion. Misoprostol has been proposed as an agent to ease IUD insertion and decrease associated pain. However, its effi cacy in the literature is inconclusive and its use varies widely between health...