474 P&T® • September 2007 • Vol. 32 No. 9 NEW DRUGS Low-Dose, 365-Day Contraceptive (Lybrel) Wyeth’s new oral contraceptive, consisting of levonorgestrel 90 mcg/ethinyl estradiol 20 mcg (Lybrel), is now available by prescription in pharmacies. This is the first low-dose combination tablet that can be taken 365 days a year, without a placebo phase or a pill-free inter val. Lybrel provides women ...

Aims and Objectives: The aims objectives of the study are to compare mean induction abortion interval efficacy intra-vaginal misoprostol alone versus combined use intravaginal intracervical Foley catheter in termination mid-trimester pregnancy. Methods: This was prospective, comparative conducted during March 2021 April 2022 at Department Obstetrics Gynaecology, SMS Medical College, Jaipur. inc...

the present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. the obtained microcapsules were discrete, spherical with free flowing properties and ...

Objectives. To compare the efficacy and safety of intravaginal misoprostol with transcervical Foley catheter for labour induction. Material and Methods. One hundred and four women with term gestation, with Bishop score < 4, and with various indications for labour induction were randomly divided into two groups. In Group I, 25 μg of misoprostol tablet was placed intravaginally, 4 hourly up to ma...

Background: Therapies available for thin endometrium are limited and mostly performed experimentally which most of these treatments have a similar function increase blood flow to the endometrium, causing it thicken develop. The aim study was compare effect estradiol valerate in combination with sildenafil on endometrial thickness infertile women before intrauterine insemination. Methods: In thi...

The efficacy and tolerability of 80 mg propranolol tablets as a vaginal contraceptive were studied in 198 fertile women for 11 months. The calculated one year life table pregnancy rate was 3.4/100 women and the Pearl index was 3.9/100 women years. No major adverse effects were encountered. The findings suggested that propranolol is an effective vaginal contraceptive whose failure rate compares ...

introduction urogenital atrophy is a common problem after menopause, and results from declining estradiol levels and may causes symptoms that can significantly affect quality of life. the aim of this study was to determine the effect of the vaginal suppository of vitamin e in the treatment of atrophic vaginities. materials and methods this randomized, double-blind controlled trail study was car...

A new vaginal ring technology, the insert vaginal ring (InVR), is presented. The InVR overcomes the current shortfall of conventional vaginal rings (VRs) that are generally ineffectual for the delivery of hydrophilic and/or macromolecular actives, including peptides, proteins and antibodies, due to their poor permeation characteristics in the hydrophobic polymeric elastomers from which VRs are ...

Bacterial vaginosis (BV) is the commonest cause of vaginal discharge in women of childbearing age. Oral metronidazole has long been established as an effective therapy in the treatment of BV. However, adverse effects due to metronidazole are frequent and this may lead to problems with adherence to a 7-day course of treatment and subsequently result in treatment failure. Oral tinidazole has been...