The vanadium-containing chloroperoxidase from the fungus Curvularia inaequalis is heterologously expressed to high levels in the yeast Saccharomyces cerevisiae. Characterization of the recombinant enzyme reveals that this behaves very similar to the native chloroperoxidase. Site-directed mutagenesis is performed on four highly conserved active site residues to examine their role in catalysis. W...

The study of the effects exerted by vanadium on living systems has recently became an object of growing interest. In fact, the possibility to develop vanadium as a new drug in the treatment of diabetes and cancer calls for the individuation of the cellular vanadate-sensitive targets. Moreover, the fact that vanadium can be an environmental pollutant in urban and industrial areas, as a consequen...

When amphipathic cationic drugs are added to intact human RBCs. the RBCs first undergo a stomatocytic shape change and then. if relatively large amounts of drug are added and if the metabolic state of the RBC is appropriate. endocytic vacuoles form. Vanadate has a structural similarity to the transition state of phosphate. which presumably accounts for its ability to inhibit phosphohydrolases. ...

Multifunctionality of vanadate garnet phosphors in latent fingerprint detection, security inks, and dual-mode temperature sensing.

In the title organic-inorganic hybrid vanadate complex, [Cu(2)V(6)O(17)(C(10)H(8)N(2))(4)](n), the Cu(II) atom is six-coordinated by two chelating 2,2'-bipyridine (bipy) ligands and two vanadate O atoms in a distorted octa-hedral geometry. Two [Cu(bipy)(2)V(3)O(8)] units are linked by a bridging O atom, which lies on an inversion center, forming a dimeric unit. The dimeric units are further con...

A high resolution crystal structure of Escherichia coli alkaline phosphatase in the presence of vanadate has been refined to 1.9 A resolution. The vanadate ion takes on a trigonal bipyramidal geometry and is covalently bound by the active site serine nucleophile. A coordinated water molecule occupies the axial position opposite the serine nucleophile, whereas the equatorial oxygen atoms of the ...

This research reports a facile ultrasonic approach for the synthesis of iron vanadate (FeVO4) nanoparticles with the aid of ammonium metavanadate (NH4VO3) and Fe(NO3)3.9H2O as the starting reagents without adding external surfactant, capping agent or template in an aqueous solution. Furthermore, to examine the solar cell application of as-synthesized iron vanadate (FeVO4) nanoparticles, FTO/TiO...

The 90-kDa heat-shock protein (Hsp90) is a molecular chaperone that aids the folding of nuclear hormone receptors and protein kinases. Hsp90 x protein complexes can be stabilized by molybdate and by other transition metal oxyanions such as vanadate. Our earlier findings [Csermely, P., Kajtár, J., Hollósi, M., Jalsovszky, G., Holly, S., Kahn, C. R., Gergely, P. Jr, Söti, C., Mihály, K. & Somogyi...

In many tissues, the level of cytoplasmic calcium mediates cell function. Since cytoplasmic calcium is often maintained at a low level by active calcium extrusion, we examined whether calcium-stimulated ATPase is present in the rabbit ciliary epithelium. A technique was developed to measure calcium-stimulated ATPase in a partially enriched plasma membrane preparation. The enhancement of Na,K-AT...