the pharmacokinetic parameters of ceftazidime, a third generation cephalosporin, were investigated in six buffalo calves after single intravenous (iv) and intramuscular (im) administration at a dose rate of 10 mg/kg body weight. ceftazidime concentrations in plasma and urine were determined by microbiological assay. ceftazidime disposition was best fitted by a two-compartmental and a one-compar...

Recently a self-calibrating SMASH technique, AUTO-SMASH, was described. This technique is based on PPA with RF coil arrays using auto-calibration signals. In AUTO-SMASH, important coil sensitivity information required for successful SMASH reconstruction is obtained during the actual scan using the correlation between undersampled SMASH signal data and additionally sampled calibration signals wi...

Let h and G be, respectively, the class number and the class group of a complex cubic field of discriminant A. A method is described which makes use of recent ideas of Lenstra and Schoof to develop fast algorithms for finding h and G. Under certain Riemann hypotheses it is shown that these algorithms will compute h in 0(|A|1/5 + E) elementary operations and G in 0(|A|l/4 + F) elementary operati...

Potatoes are among the four most important staple crops worldwide. Verticillium wilt in potatoes caused by dahliae is a devastating disease that difficult to control. To identify potential avenues for control, pathogenicity of 72 V. isolates was tested here. We also resistance virulent isolate (Vd-36) induced attenuated Gibellulopsis nigrescens Vn-1 potatoes. Induction strongest when using inoc...

Objective Amikacin pharmacokinetics (PK) in children display large variability due to maturational and disease-related covariates. The objective was explore amikacin PK a pediatric oncology cohort, taking into account within-patient changes. Materials methods Clinical data therapeutic drug monitoring (TDM) observations were collected retrospectively from with an diagnosis receiving during febri...

Vitamin D (VD) is a key factor in calcium-phosphorus metabolism. In addition, it has increasing popularity due to its pleiotropic effects: renal protection, antineoplastic properties, and diabetes mellitus and hypertension control. The VD axis is severely impaired in chronic kidney disease. The changes are present even in the earliest stages and progress as kidney function worsens. Significant ...

The prognosis of acute myeloid leukemia (AML) in elderly (≥65 years) patients is poor and treatment remains non-consensual especially for those who are not eligible for intensive therapies. Our group has shown that in vitro the iron chelator deferasirox (DFX) synergizes with vitamin D (VD) to promote monocyte differentiation in primary AML cells. Herein, we present results from a retrospective ...

Whereas epidemiological data strongly link vitamin D (VD) deficiency to childhood asthma, the underlying molecular mechanisms remain unknown. Although VD is known to stimulate alveolar epithelial-mesenchymal interactions, promoting perinatal lung maturation, whether VD supplementation during this period protects against childhood asthma has not been demonstrated experimentally. Using an in vivo...

Atopic dermatitis (AD) affects 10% to 20% of children worldwide. Its severity may be inversely correlated with 25-hydroxyvitamin D (25OHD) levels. Although low levels of vitamin D (VD) can cause rickets in infants, VD deficiency rickets is an unusual presentation in teenagers. We report the case of a 14-year-old girl with severe AD and fish allergy since early childhood. She lived at high latit...

Hemiscorpius lepturus (H. lepturus) is one of the most dangerous scorpions in Iran. Intramuscular administration (IM) of available Razi antivenom to H. lepturus venom is used by many of Iranian clinicians. The purpose of the current study was to investigate the efficiency of IM route for treatment of envenomed patients by H. lepturus. We compared the pharmacokinetics parameters of venom and ant...