BACKGROUND Cardiogenic dysfunction with acute renal failure (ARF) and diuretic drug resistance increases mortality after cardiac surgery with cardiopulmonary bypass (CPB) in adults. Until few years ago, intermittent renal replacement therapy (IRRT) was the only therapeutical strategy proposed to such patients. Few data are available in the literature regarding the use of continuous veno-venous ...

A potential application of the continuous renal replacement therapies is the extracorporeal removal of inflammatory mediators in septic patients. Cytokine elimination with continuous renal replacement therapies has been demonstrated in several clinical studies, but so far without important effects on their serum concentrations. Improved knowledge of the cytokine removal mechanisms could lead to...

Dosage recommendations for cidofovir are available for renally competent as well as impaired patients; however, there are no data for patients undergoing continuous renal replacement therapy. We determined the single-dose concentration-versus-time profile of cidofovir in a critically ill patient undergoing continuous venovenous hemofiltration (CVVH). One dose of 450 mg cidofovir (5 mg/kg) was a...

I read with interest the recent article by Schilder et al. reporting that plasma levels and the biomarker value of neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with acute kidney injury (AKI) are not affected by continuous venovenous hemofiltration (CVVH) [1]. Recently, Honore et al. [2] commented on the data by Schilder et al., suggesting that further studies are...

INTRODUCTION Emergency transplantation of a donor liver that is not matched for the major blood antigens can produce marked immune-mediated cytokine release that can cause donor graft loss. Control of the inflammatory response may be a key element in treatment. METHODS We present the case of a 46-year-old man with primary graft nonfunction after liver transplantation who underwent emergency r...

BACKGROUND In patients with suspected heparin-induced thrombocytopenia (HIT) who need renal replacement therapy, a nonheparin anticoagulant has to be chosen to prevent thrombosis in the extracorporeal circuit. Danaparoid, a low-molecular-weight heparinoid consisting of heparan sulphate, dermatan sulphate, and chondroitin sulphate, is recommended for systemic anticoagulation in patients with HIT...

We evaluated vancomycin levels as recent guidelines for therapeutic monitoring of vancomycin (not available at the time these data were collected) recommend trough levels of 15 to 20 μg/mL; however, this may be more difficult to achieve in patients with accelerated vancomycin clearance, such as burn patients or recipients of continuous venovenous hemofiltration (CVVH) therapy. We retrospectivel...

OBJECTIVE To test the ability of a novel super high-flux (SHF) membrane with a larger pore size to clear myoglobin from serum. SETTING The intensive care unit of a university teaching hospital. SUBJECT A patient with serotonin syndrome complicated by severe rhabodomyolysis and oliguric acute renal failure. METHOD Initially continuous veno-venous hemofiltration was performed at 2 l/hour ul...

AAMI American Association of Medical Instrumentation ACCP American College of Chest Physicians ACD-A Anticoagulant dextrose solution A ACE-I Angiotensin-converting enzyme inhibitor(s) ADQI Acute Dialysis Quality Initiative AHCPR Agency for Health Care Policy and Research AKD Acute kidney diseases and disorders AKI Acute kidney injury AKIN Acute Kidney Injury Network ANP Atrial natriuretic pepti...