THULESIUS, OLAV, AND PAUL C. JOHNSON. Beand postcapillary resistance in skeletal muscle. Am. J. Physiol. 2 IO(~) : 869-872. I g66.-Experiments were performed on an isolated muscle preparation of the dog’s hindlimb to determine the effect of changing arterial pressure on arterial and venous resistance of skeletal muscle. Reduction of arterial pressure caused a reduction in arterial resistance ov...

The mean and range of venous pressure values in the various body surface areas is presented. Attention is directed to the variability of these values, the constantly decreasing pressure gradient towards the heart, and the essentially equal pressures in corresponding veins on opposite sides of the body. The importance of accurately identifying the vein is emphasized. The relation of venous press...

Spontaneously hypertensive rats are less susceptible than normotensive rats to disruption of the blood-brain barrier during acute hypertension. The purpose of this study was to examine mechanisms that protect the blood-brain barrier from disruption in chronically hypertensive rats during acute hypertension. Normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (S...

These studies attempted to distinguish between the various intrinsic mechanisms which might be responsible for the increase in vascular resistance seen in the intestine with venous pressure elevation (the venous-arteriolar response). Intra-arterial infusion of procaine did not block the response, indicating that a local reflex is not involved. However, the resistance increase was greatly modifi...

Traumatic brain injury and stroke are both characterized by an ischemic core surrounded by a penumbra of low to hyperemic flows. The underperfused ischemic core is the focus of edema development, but the source of the edema fluid is not known. We hypothesized that flow of edema fluid into the tissue is derived from cerebral venous circulation pressure, which always exceeds intracranial pressure...

BACKGROUND Poor oxygenation might occur in transplanted lungs as a result of reperfusion injury and lack of lymphatic drainage. Low central venous and pulmonary capillary wedge pressures are advocated to reduce pulmonary edema and maximize oxygenation but might adversely affect cardiac index, circulation, and renal function. METHODS Histories, intensive care unit charts, and donor data on 118...

Elevated right atrial (RA) pressure is associated with renal impairment and increased mortality in patients with heart failure. Raised jugular venous pressure, as a bedside estimate of RA pressure, has similarly been shown to be associated with adverse outcome with increased heart failure hospitalizations and death. RA pressure (and jugular venous pressure) normally falls during inspiration des...

Recent studies challenge the utility of central venous pressure monitoring as a surrogate for cardiac preload. Starting with Starling's original studies on the regulation of cardiac output, this review traces the history of the experiments that elucidated the role of central venous pressure in circulatory physiology. Central venous pressure is an important physiologic parameter, but it is not a...

BACKGROUND Recent radiological studies have shown that arteriovenous malformations with impaired venous drainage may be susceptible to hemorrhage. To evaluate this hypothesis using a hemodynamic approach, we measured intravascular pressure during surgery in three patients with arteriovenous malformation. SUMMARY OF REPORT In three patients we measured intravascular pressures in the draining v...