Prostate cancer is the most prevalent malignancy and the second leading cause of cancer mortality in men. Early growth response gene-1 (EGR-1) plays a crucial role in the development and progression of prostate cancer. The presented data show that EGR-1 differs in cellular localization in benign cells compared with malignant prostate cells and that this localization is critical for the transcri...

OBJECTIVES The excess proliferation of vascular smooth muscle cells (VSMCs) and the development of intimal hyperplasia is a hallmark of vein graft failure. This study aimed to verify that a single intraoperative transfection of early growth response gene-1 (Egr-1) decoy oligonucleotide (ODN) can suppress vein graft proliferation of VSMCs and intimal hyperplasia. METHODS In a rabbit model, jug...

Early growth response gene (Egr)-2 is important for the maintenance of T cell homeostasis and controls the development of autoimmune disease. However, the underlying mechanisms are unknown. We have now discovered that Egr-2, which is induced by TGF-β and IL-6, negatively regulates the expression of IL-17, but not IL-2 or IFN-γ, in effector T cells. In the absence of Egr-2, CD4 T cells produce h...

In this article we have made an attempt to survey some results on performance of jet ejector. The literature is also reviewed to pursue further work in this area. Key wordsHEVS, EVS, jet ejector, performance of venture scrubber, characteristics of jet ejector, efficiency

In-cylinder exhaust gas recirculation (EGR) stratification, generally achieved by supplying EGR asymmetrically into intake ports on a four-valve diesel engine, is sensitive to trapped exhaust gas in the intake manifold and intake ports that is caused by the continuous supply of EGR during the valve-close periods of the intake valves. The subject of this study is to evaluate the distribution of ...

operating an engine with homogeneous charge compression ignition (hcci) technique is a promising technique to lower nox and pm emissions of engines while achieving high efficiency and lower fuel consumption. nevertheless, applications for hcci are still limited due to the absence of a definite means to control ignition timing and narrow operating region. a single cylinder diesel engine with com...

Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor with key roles in mediating fibrotic TGF-ß responses. To elucidate Egr-1 function in SSc-associated fibrosis, we examined change in gene expre...

There is little known about the regulation of gene expression during TCR-mediated differentiation of immature CD4+8+ (double positive) thymocytes into mature T cells. Using the DPK CD4+8+ thymocyte precursor cell line, we demonstrate that the early growth response-1 gene (Erg-1), encoding a zinc finger transcription factor, is rapidly upregulated after TCR stimulation. We also report that Egr-1...

To investigate the role of the Egr family of transcription regulatory factors in neuronal apoptosis, we examined the effect of a dominant negative Egr inhibitor construct in a well characterized in vitro paradigm, cerebellar granule cell death induced by withdrawal of depolarizing concentrations of extracellular potassium. We found that this apoptotic stimulus increases the activity of a report...