Purified calf brain tubulin has been induced to self-aggregate in vitro into paracrystalline structures by the anti-cancer drug vinblastine. The size, shape, optical birefringence, and drug stoichiometry of these tubulin-vinblastine paracrystals are similar to those of paracrystals formed in vivo. Similar structures can be formed with vincristine and desacetylvinblastine, but not with colchicin...

Abstract The experiment was carried out in a greenhouse at the University of Diyala’s Research Station for Department Horticulture and Landscaping College Agriculture during 2020–2021 academic year. Experiments were conducted on Catharanthus roseus cv. ‘Pacifica XP’ from November 24, 2020, to June 1, 2021, effects adding copper 0, 30, 45, 60 mg L -1 , foliar spraying with benzoic salicylic acid...

A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.

The presence in orange juice of compounds that specifically inhibit the P-glycoprotein (P-gp) drug efflux transporter, but not the cytochrome P450 (CYP) isozyme CYP3A4, was investigated. The uptake of [(3)H]vinblastine, a substrate of P-gp, by Caco-2 cells was measured. An ethyl acetate extract of orange juice did not affect the initial uptake rate of [(3)H]vinblastine but significantly increas...

This nonblinded, multicenter, randomized phase III study compares the median time to progression (primary endpoint), response rate, and quality of life, safety, and survival of docetaxel (Taxotere) vs mitomycin (Mutamycin) plus vinblastine (Velban) in patients with metastatic breast cancer in whom previous anthracycline-containing chemotherapy has failed. Patients were randomized to receive an ...

Background: Annually, various types of cancer cause thousands deaths globally, and identifying an appropriate therapeutic option for these disorders is crucial importance. Side effects anticancer drugs can be reduced through the promising strategy combination therapy. Objectives: The present paper has investigated in vitro cytotoxicity Taxol, carboplatin, vinblastine, vincristine alone against ...

The ability of P-glycoprotein (P-gp) to transport naturally occurring and synthetic opiate analgesics was investigated. Multidrug-resistant Chinese hamster ovary cells (B30) were found to accumulate significantly lower amounts of morphine than their drug-sensitive counterparts (B1). This decreased accumulation was reversed upon depletion of cellular stores of ATP. In addition, morphine bound to...

Endophytic fungi reside in a symbiotic fashion inside their host plants, mimic their chemistry and interestingly, produce the same natural products as their hosts and are thus being screened for the production of valuable compounds like taxol, camptothecin, podophyllotoxin, etc. Vinblastine and vincristine are excellent anti-cancer drugs but their current production using plants is non-abundant...

When vinblastine was injected into the internal carotid artery of individuals with intracranial neopla.sms, it usu ally caused a prompt oculocutaneous toxicity. Though less severe, the direct local effects simulated the histo toxicity of the alkylating agents (6, 7, 9, 12, 13). Intra arterial infusion of hydrogen peroxide was reported to increase selectively the uptake of several radioactive co...