Members of the Apocynaceae plant family produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patterns that are responsible for their various biological activities. A novel N-methyltransferase involved in the vindoline pathway in Catharanthus roseus showing distinct similarity to γ-tocopherol C-methyltransferases was used in a bioinformatic screen of transc...

Catharanthus roseus (C. roseus) and Vinca minor (V. minor) are two common important medical plants belonging to the family Apocynaceae. In this study, we used non-targeted GC-MS and targeted LC-MS metabolomics to dissect the metabolic profile of two plants with comparable phenotypic and metabolic differences. A total of 58 significantly different metabolites were present in different quantities...

background & aim: investigation of suspension cell culture and callus production in catharanthus roseus. catharanthus roseus is an herbaceous perennial plant belongs to the family apocynaceae. c. roseus is important as commercial medicinal plant because of its alkaloidal content. whole plant contains about 130 alkaloids those are classified as vinca alkaloids. vincristine and vinblastine; t...

Vincristine, an alkaloid of periwinkle plant (vinca) used in the treatment of various malignancies. The experimental group included 36 male wistar albino rats. The animals were divided into four groups of nine animals each. The animals received same dose of vincristine 1 mg/kg b.w. given intragastrically through a ne rubber catheter reaching lower third of oesophagus. Equal number of controls ...

In this study, the epiphytic algae of Lemna minor collected from its natural habitat or grown in aquarium were analyzed for a period of six months from April 2016 to September 2016. While a total of 15 taxa, 1 belonging to Cyanophyta and 14 belonging to Bacillariophyta, were recorded for L. minor grown in aquarium, a total of 36 taxa, 3 belonging to Cyanophyta, 5 belonging to Chlorophyta, 1 bel...

The most commonly reported reason for errors is that a syringe containing a vinca alkaloid is mistaken for a syringe containing an intrathecal medication. Very few medications, including chemotherapeutic agents, can be administered safely into the intrathecal space. Most intrathecal chemotherapy errors involve the accidental injection of vincristine; however, all of the vinca alkaloids (vinblas...