Abstract Pseudorabies virus (PRV) is a double-stranded DNA with genome approximating 150 kb in size. PRV contains many non-essential genes that can be replaced encoding heterogenous antigens without affecting viral propagation. With the ability to induce cellular, humoral and mucosal immune responses host, considered an ideal potential live vector for generation of animal vaccines. In this revi...

The T(c)-cell response to ectromelia virus infection was studied in BALB/c-H-2(db) mice which carry a loss mutation in the H-2D region that results in the absence from cell surfaces of a molecule (D') bearing certain public H-2 specificities. When infected, these mice showed a poor response of T(c) cells that recognize H-2D(d) plus virus-specific determinants on infected macrophage targets, but...

The early region of the polyoma genome encodes three T antigens. We have analyzed the organization of the coding regions for the T antigens, using the nucleotide sequence of polyoma DNA and peptides derived from purified, radio-labeled T antigens, separated by two-dimensional electrophoresis and chromatography. We compared the peptides, predicted from the nucleotide sequence of the DNA, with th...

Induced autoimmunity or autoinflammatory-like conditions as a rare vaccine-related adverse event have been reported following COVID-19 vaccination. Such inadvertent reactions raised somewhat concerns about the long-term safety of developed vaccines. multifactorial phenomena may be related to cross-reactivity between viral-specific antigens with host self-proteins through molecular mimicry mecha...