Many viruses target cytoplasmic polyA binding protein (PABPC) to effect widespread inhibition of host gene expression, a process termed viral host-shutoff (vhs). During lytic replication of Epstein Barr Virus (EBV) we observed that PABPC was efficiently translocated from the cytoplasm to the nucleus. Translocated PABPC was diffusely distributed but was excluded from viral replication compartmen...

In this paper we study the steady state availability of main k-out-of-n: F and secondary subsystems having general repair time distribution. When more than k units of main subsystem fail, then the main subsystem shuts off the secondary subsystem. The life time distributions of the main units and that of secondary subsystem are exponentially distributed. A repair facility having single repairman...

in order to assess the influence of breed on the vertebral heart scale (vhs) of dogs, the vhs was measured and compared in left to right (ll) and right to left lateral (rl) views. for all dogs (n=56), the mean vhs on the rl radiographs [9.7 vertebra (v)] was significantly larger than the mean vhs on the ll radiographs (9.6 v) (p=0.047). doberman dogs had higher mean values of the vhs in ll (9.9...

Viruses use virions to spread between hosts, and virion composition is therefore the primary determinant of viral transmissibility and immunogenicity. However, the virions of many viruses are complex and pleomorphic, making them difficult to analyse in detail. Here we address this by identifying and quantifying virion proteins with mass spectrometry, producing a complete and quantified model of...

BACKGROUND In canine mitral regurgitation (MR) the rate of heart enlargement increases in the last year before congestive heart failure (CHF). Measurement of heart size and its rate of increase may be useful tests for CHF in MR. OBJECTIVES To determine the value of vertebral heart scale (VHS) and its rate of increase (∆VHS units/month) for diagnosing the presence and predicting the onset of C...

Abstract The structural design of a mechanical temperature-driven shut-off valve used in the water and steam sampling device power plant is designed using Iventor drawing software. A NiTi shape memory alloy with high temperature-sensitivity as driven spring to control opening closing valve. In addition structures common parts valve, calculation parameter-design are also carried out. unimpeded c...

A regulated switch between latent and lytic gene expression is common to all known herpesviruses. However, the effects on host colonization of altering this switch are largely unknown. We deregulated the transcription of the gene encoding the major lytic transactivator of murine gammaherpesvirus-68, ORF50, by inserting a new and powerful promoter element in its 5' untranslated region. In vitro,...