The recent outbreak of COVID-19 is considered to be one of the biggest disasters faced in the history which has already killed 211568 and effected 3065739 people across the world (As on 28th April 2020). Thus, there is an alarming need to discuss novel treatment strategies for treatment of such viral outbreaks. Viral diseases affect millions of people around the world, with a major effect on hu...

Layered double hydroxide (LDH)@SiO2 nanoparticles were developed as a delivery carrier for the plasmid DNA expressing the Newcastle disease virus F gene. The LDH was hydrotalcite-like materials. The plasmid DNA encapsulated in the LDH@SiO2 nanoparticles (pFDNA-LDH@SiO2-NPs) was prepared by the coprecipitation method, and the properties of pFDNA-LDH@SiO2-NPs were characterized by transmission el...

We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of induci...

This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they ...

The rod-shaped plant virus tobacco mosaic virus (TMV) is widely used as a nano-fabrication template, and chimeric peptide expression on its major coat protein has extended its potential applications. Here we describe a simple bacterial expression system for production and rapid purification of recombinant chimeric TMV coat protein carrying C-terminal peptide tags. These proteins do not bind TMV...

Plant viruses are considered as nanobuilding blocks that can be used as synthons or templates for novel materials. Cowpea mosaic virus (CPMV) particles have been shown to template the fabrication of metallic nanoparticles by an electroless deposition metallization process. Palladium ions were electrostatically bound to the virus capsid and, when reduced, acted as nucleation sites for the subseq...

Milbemycins are macrolide antibiotics with a broad spectrum of nematocidal, insecticidal, and acaricidal activity. To obtain milbemycin A₃/A₄ derivatives suitable for chemical conjugation to protein carriers (milbemycin haptens), succinate linker and a novel 17-atom-long linker containing a terminal carboxylic acid group were attached to the milbemycin core in a protecting group-free synthesis....

We developed a new generation of superhydrophobic chips optimized for probing ultrasmall sample quantities by X-ray scattering and fluorescence techniques. The chips are based on thin Si3N4 membranes with a tailored pattern of SU-8 photoresist pillars. Indeed, aqueous solution droplets can be evaporated and concentrated at predefined positions using a non-periodic pillar pattern. We demonstrate...

The application of nanoparticles in targeted drug delivery has dramatically increased in recent years. Nanocarriers including synthetic polymers, liposomes, and telodendrimers have been proposed and investigated thoroughly. However, a need remains to address several limitations such as, toxicity, inability to accumulate a sufficient number of molecules to the cytoplasm through target cell inter...