Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation of de novo vascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present...

This paper presents an evaluation of the impact of several architectural parameters on the performance of Virtual Memory (VM) based cache coherence schemes for shared-memory multiprocessors. The VM-based cache coherence schemes use the traditional VM translation hardware on each processor to detect memory access attempts that might leave caches incoherent, and maintain coherence through VM-leve...

In this paper, we present a novel multi-objective ant colony system algorithm for virtual machine (VM) consolidation in cloud data centers. The proposed algorithm builds VM migration plans, which are then used to minimize over-provisioning of physical machines (PMs) by consolidating VMs on under-utilized PMs. It optimizes two objectives that are ordered by their importance. The first and foremo...

Virtual machine (VM) placement is a fundamental problem about resource scheduling in cloud computing; however, the design and implementation of an efficient VM placement algorithm are very challenging. To better multiplex and share physical hosts in the cloud data centers, this paper presents a VM placement algorithm based on the peak workload characteristics, which models the workload characte...

Vasculogenic mimicry (VM) is a vascular-like structure which can mimic the embryonic vascular network pattern to nourish the tumour tissue. As a unique perfusion way, VM is correlated with tumour progression, invasion, metastasis and lower 5-year survival rate. Notably, epithelial-mesenchymal transition (EMT) regulators and EMT-related transcription factors are highly up-regulated in VM-forming...

The flux of teniposide (VM-26) across the cell membrane was compared for L1210 cells, nine VM-26-resistant L1210 sublines, and three partially revertant lines. The nine resistant sublines were maintained in medium with VM-26. A "zero-time," temperature-independent binding of VM-26 to cells, attributable to adsorption on the cell membrane or to solvation in the membrane, varied independently of ...

The cartilage matrix is composed of characteristic components including type II collagen, aggrecan and link protein. In this paper, we report two DNA elements that regulate the link protein gene. Using transient transfection assays with link protein gene constructs in chondrocytes, chloramphenicol acetyl transferase (CAT) assays were used to measure the transcriptional activity of the link prot...

VM/Pass-Through, an interactive networking facility, has gained widespread acceptance within ISM and with ISM customers. Pass-Through allows a single terminal access to many different computers, including those at distant locations. In building Pass-Through, and in observing its growing use, we have had an opportunity to study the practical implications of this facility and of our approach to i...

Anti-angiogenic therapy has shown promising but insufficient efficacy on gliomas. Recent studies suggest that vasculogenic mimicry (VM), or the formation of non-endothelial, tumor-cell-lined microvascular channels, occurs in aggressive tumors, including gliomas. There is also evidence of a physiological connection between the endothelial-lined vasculature and VM channels. Tumor cells, by virtue...

Underutilization of computing resources and high power consumption are two primary challenges in the domain of Cloud resource management. This paper deals with these challenges through offline, migration impact-aware, multi-objective dynamic Virtual Machine (VM) consolidation in the context of large-scale virtualized data center environments. The problem is formulated as an NP-hard discrete com...