Estrogen potentiates vascular reactivity to vasopressin (VP) by enhancing constrictor prostanoid function. To determine the cellular and molecular mechanisms, the effects of estrogen on arachidonic acid metabolism and on the expression of constrictor prostanoid pathway enzymes and endoperoxide/thromboxane receptor (TP) were determined in the female rat aorta. The release of thromboxane A2 (TxA2...

Multiple processors can be used to speed up a backward-chaining deduction by distributing or-parallel deductions. However, the actual speedup obtained is strongly dependent on the amount of communication required for the task allocation strategy. A Variable Supply Model (VSM) is presented for multiple processors with replicated databases on a broadcast network. The term model refers to the set ...

Most studies on document clustering till date use Vector Space Model (VSM) to represent documents in the document space, where documents are denoted by a vector in a word vector space. The standard VSM does not take into account the semantic relatedness between terms. Thus, terms with some semantic similarity are dealt with in the same way as terms with no semantic relatedness. Since this uncon...

Value Stream Mapping (VSM) is a functional approach to reorganizing production system in line with lean vision. It has been applied in many sectors to improve performance. However, there are several factors that need to be considered while implementing VSM in practice. This paper presents a literature review of the Critical Success Factors (CSFs) in the implementation of VSM across five differe...

The role of glycogen as an oxidative substrate for vascular smooth muscle (VSM) remains controversial. To elucidate the importance of glycogen as an oxidative substrate and the influence of glycogen flux on VSM substrate selection, we systematically altered glycogen levels and measured metabolism of glucose, acetate, and glycogen. Hog carotid arteries with glycogen contents ranging from 1 to 11...

Although vascular smooth muscle (VSM) derives the majority of its energy from oxidative phosphorylation, controversy exists concerning which substrates are utilized by the tricarboxylic acid (TCA) cycle. We used 13C isotopomer analysis of glutamate to directly measure the entry of exogenous [13C]glucose and acetate and unlabeled endogenous sources into the TCA cycle via acetyl-CoA. Hog carotid ...

Vascular smooth muscle (VSM) cell proliferation contributes to the pathogenesis of atherosclerosis, restenosis after angioplasty and vein graft disease. The regulation of genes involved in VSM cell proliferation, particularly by naturally occurring inhibitors, is therefore of some importance. We have investigated the role of the c-myc proto-oncogene in growth arrest of exponentially proliferati...

This paper presents developments of traditional value stream mapping (VSM) related to enhancing system and method competencies of both individuals and organisations. Since systematic immersions in traditional VSM – a highly accepted technique for improving production systems – are necessary, this paper describes from a production research point of view approaches for systematic productivity inc...

Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has been generally considered protective in cardiac and vascular tissues and has been the target of numerous basic science and clinical studies. In this project, the influence of...

The decompensatory phase of hemorrhage (shock) is caused by a poorly defined phenomenon termed vascular hyporeactivity (VHR). VHR may reflect an acute in vivo imbalance in levels of contractile and relaxant stimuli favoring net vascular smooth muscle (VSM) relaxation. Alternatively, VHR may be caused by intrinsic VSM desensitization of contraction resulting from prior exposure to high levels of...