The aim of our study was to compare the effects a gold salt (sodium tetrachloroaurate) and nanoparticles colloidal solution on morphofunctional state hypothalamus adrenal glands 6-month-old male rats with obesity, which induced using diet-induced model metabolic disorders. rats, modeled for were divided into three groups that received NaCl solution, 10 days. Rats control group standard diet. Af...

Despite its evolutionary conservation and functional importance, little is known of the signaling pathways that underlie development of the hypothalamus. Although mutations affecting Nodal and Hedgehog signaling disrupt hypothalamic development, the time and site of action and the exact roles of these pathways remain very poorly understood. Unexpectedly, we show here that cell-autonomous recept...

The starting point for the prevention of human disease is study vital functions a healthy organism, taking into account complex effects external and internal factors. More often in clinical practice, doctors observe patients with advanced pathology, when body has undergone significant changes, including at level systemic regulation (CNS, hypothalamus) intercellular signaling neuro-immune-endocr...

Abstract Objectives: The purpose of this study was to investigate whether stress affected energy metabolism and reproductive function through the glucocorticoid receptor (GR) on Kisspeptin neurons in hypothalamus. Methods: 1. first part focused effects chronic restraint mice. 2. second expression serum cortisol prolactin GR Kiss1 genes hypothalamus.3. Based above research, we constructed specif...

Somatostatin-14 (SS) significantly increased inositol-1,4,5-trisphosphate (IP3) accumulation in rat hypothalamic, striatal, frontoparietal cortical and hippocampal slices. However, this stimulation of IP3 accumulation by SS was highest in the frontoparietal cortex and hippocampus. The effect was already significant with 0.01 microM in the frontoparietal cortex (P < 0.05) and hippocampus (P < 0....

The febrile response to lipopolysaccharide (LPS) consists of three phases (phases I-III), all requiring de novo synthesis of prostaglandin (PG) E(2). The major mechanism for activation of PGE(2)-synthesizing enzymes is transcriptional upregulation. The triphasic febrile response of Wistar-Kyoto rats to intravenous LPS (50 microg/kg) was studied. Using real-time RT-PCR, the expression of seven P...

adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. ms is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

Introduction: Anorexia Nervosa is a serious psychiatric condition that has been suggested to have a neuroimmunological mechanism as a part of the pathophysiology. Hypothalamic inflammation occurs in an anorectic animal model called the anx/anx mouse in the form of up-regulation of inflammatory markers and activated microglia. However, neuroinflammation based on astrogliosis has not been studied...

In animals, obesity caused by consumption of a sweet-fat diet (SFD) is the most adequate mouse model human diet-induced obesity. Fibroblast growth factor 21 (FGF21) reduces body weight, beneficially affects taste preferences, and corrects glucose metabolism in obese mice. Sex known to influence FGF21 effects different models hereditary mice with SFD-induced obesity, have been studied only males...