Objective- Study on the effect of heparin in prevention of abdominal adhesions following abdominal surgery in rat. Design- Experimental design. Animals-Twenty male rats with average weight of 248 ± 5 gr. Procedures- Animals were randomly divided into two equal groups of 10 rats (A and B). After induction of anesthesia, a midline abdominal incision was made and intestines were manipulated ...

BACKGROUND Heparin-induced thrombocytopenia is a relatively uncommon but severe side-effect of heparin therapy. Heparin-induced IgG antibody has been elucidated to be the main isotype and the most pathogenic antibody in the pathophysiology. As affected patients are at high risk of developing thrombotic events, confirmation of the clinical diagnosis and avoidance of heparin re-exposure are impor...

Inhaled heparin prevents antigen-induced bronchoconstriction and inhibits anti-immunoglobulin E-mediated mast cell degranulation. We hypothesized that the antiallergic action of heparin may be molecular weight dependent. Therefore, we studied the effects of three different low-molecular-weight fractions of heparin [medium-, low-, and ultralow-molecular-weight heparin (MMWH, LMWH, ULMWH, respect...

Retinal vein occlusion is a frequent cause of visual loss for which few effective therapies are available. Anticoagulation with low molecular weight heparin might be of value in its treatment. We conducted a systematic review and meta analysis of randomized trials evaluating the effect of low molecular weight heparin in patients with retinal vein occlusion. Data sources included MEDLINE, EMBASE...

Background: At present, no clear evidence has been provided regarding the superiority of various heparin regimens as bridging treatment after heart surgery in patients who need chronic anticoagulation. Objectives: Aim of present pilot investigation was to prospectively compare the safety of weight adjusted enoxaparin and subcutaneous unfractionated heparin in patients undergoing valvular heart ...

We have compared the hemorrhagic and antithrombotic effects of a low molecular weight (LMW) heparin fraction and standard heparin in rabbits. Similar LMW heparin fractions have antithrombotic effects when tested in animals, but their hemorrhagic effects relative to standard heparin have not been established. Standard porcine mucosal heparin (mol wt 15,000 daltons) was depolymerized by nitrous a...

The issue of how and when to monitor low-molecular-weight heparin (LMWH) therapy was raised from the beginning of the clinical use of these compounds, almost 20 years ago. Laboratory monitoring of LMWHwas suggested mainly because the new compounds were to replace unfractionated heparin (UFH), which definitely required monitoring. In the following, we will briefly review the reasons for monitori...