High frequency oscillations are associated with normal brain function, but also increasingly recognized as potential biomarkers of the epileptogenic brain. Their role in human cognition has been predominantly studied in classical gamma frequencies (30-100 Hz), which reflect neuronal network coordination involved in attention, learning and memory. Invasive brain recordings in animals and humans ...

Due to time and resource constraints, small samples (N=3-7 cases per group) are often used in neurobiological studies that employ multiple techniques. In a simulation study, five statistical tests were used to compare two small samples (treated and control) with an unstable, additive baseline. These five tests differed in the way that they used the baseline variable (B) to adjust or normalize t...

In comparing the mean count of two independent samples, some practitioners would use the t-test or the Wilcoxon rank sum test while others may use methods based on a Poisson model. It is not uncommon to encounter count data that exhibit overdispersion where the Poisson model is no longer appropriate. This paper deals with methods for overdispersed data using the negative binomial distribution r...

Nonparametric statistical methods are useful tools for data analysis when there is reason to believe that the outcome variables of interest may fail certain distributional assumptions required for parametric methods. Variables may be ordered categories in nature and thereby not suitable for analysis methods that assume normally distributed variables, such as t tests or analyses of variance and ...

OBJECTIVE To test the hypothesis that homeopathy is effective in reducing the symptoms of joint inflammation in rheumatoid arthritis (RA). METHOD This was a 6-month randomized, cross-over, double-blind, placebo-controlled, single-centre study set in a teaching hospital rheumatology out-patient clinic. The participants of the study were 112 patients who had definite or classical RA, were serop...

An algorithm is described for the nonnegative rank factorization (NRF) of some completely positive (CP) matrices whose rank is equal to their CP-rank. The algorithm can compute the symmetric NRF of any nonnegative symmetric rank-r matrix that contains a diagonal principal submatrix of that rank and size with leading cost O(rm) operations in the dense case. The algorithm is based on geometric co...

Methods All HIV1-positive patients of the participating clinic wards, aged over 13 and giving informed consent are included in the cohort. Patients receiving a first prescription of NVP between 1997 and 2008 are described at baseline and during follow-up according to their treatment status, ART-naïve or not. Chi-square test, signed rank Wilcoxon test, Mc Nemar test and log-rank test are used fo...

INTRODUCTION Among patients with acute myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen(®) (DAC), Eisai Inc., Woodcliff Lake, NJ, USA] compared with treatment choice (TC): at primary analysis the hazard ratio (HR) was 0.85 (95% confidence interval 0.69-1.04; stratified log-rank P = 0.108). With two interim analyses, two-sided alpha was ...

Wireless sensor network (WSN) coverage problem is to think about how maximize the obtain reliable monitoring and tracking services with guaranteed quality of service. In this paper, a simplified slime mould algorithm (SSMA) for solving WSN proposed. SSMA, we mainly conducted 13 groups WSNs optimization experiments compared them six well-known meta-heuristic algorithms. The experimental results ...

PURPOSE To study age-related changes in corneal deformation response to air-puff applanation tonometry. METHODS Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflu...