Clinical trials are expensive. Understanding where a trial is needed and what questions to address is therefore important. We ask if pilot work using observational healthcare data can be used to inform a trial. Symptoms of significant psychological distress are common in cancer patients but are often left untreated. It is unknown to what extent such distress symptoms persist over time and requi...

Heavy Menstrual Bleeding (HMB) is common and existing treatments often ineffective. The MRC funded DexFEM trial aims to investigate whether oral dexamethasone (Dex; a glucocorticoid) reduces HMB. Our integrated approach to the development of a Bayesian response-adaptive dose-finding study uses SAS for data handling, generating scripts and executing analysis in WinBUGS. The clinical aims are two...

A common problem in ethology is ranking of animal preferences for several discrete stimuli or options. We considered experiments where animals chose one of all possible simultaneously presented options. The animals might be observed at repeated occasions. In the ethological literature the analysis is often focused on testing the global hypotheses of no difference in preferences by non-parametri...

Statistical science and metrology are intertwined. Measurement quality affects what can be learned from data collected and processed using statistical methods, and appropriate data collection and analysis quantifies the quality of measurements. Metrologists have long understood this and have often developed their own statistical methodologies and emphases. Some statisticians, notably those work...

BACKGROUND Hypertension is considered as a major public health problem in most countries due to its association with ischemic heart disease which causes cerebrovascular disease and death. OBJECTIVES The purpose of the present study was to study factors affecting Blood Pressure (BP). PATIENTS AND METHODS The data were extracted from annual observation of the workers who worked in Polyacryl I...

Traditionally, state-space models are fitted to data where there is uncertainty in the observation or measurement of the system. State-space models are partitioned into an underlying system process describing the transitions of the true states of the system over time and the observation process linking the observations of the system to the true states. Open population capture-recapture-recovery...

BACKGROUND Venom-induced consumption coagulopathy (VICC) is an important feature of snake envenoming. AIM To investigate the effect of antivenom and fresh frozen plasma (FFP) on recovery of VICC in Australian elapid snake envenoming. DESIGN Prospective cohort study. METHODS Patients with VICC were included from the Australian Snakebite Project (ASP). Time to recovery of VICC (defined as t...

BACKGROUND Chinese herbal injections (CHIs) are commonly used for the treatment of heart failure in China. Due to the variety of CHIs used in clinic, selecting a suitable CHI for patients with heart failure is vital. This study aims to assess and compare the effect of different CHIs for heart failure using network meta-analysis (NMA). METHODS Six electronic databases, including PubMed, the Co...

Dengue Hemorrhagic Fever (DHF) is a tropical disease that always attacks densely populated urban communities. Some factors, such as environment, climate and mobility, have contributed to the spread of disease. The Aedes aegypti mosquito an agent dengue virus in humans, by inhibiting its life cycle it can reduce Therefore, necessary involve dynamics mosquito's model order obtain reliable risk ma...