Flexible designs offer a large amount of flexibility in clinical trials with control of the type I error rate. This allows the combination of trials from different clinical phases of a drug development process. Such combinations require designs where hypotheses are selected and/or added at interim analysis without knowing the selection rule in advance so that both flexibility and multiplicity i...

In this paper we present a new R package called sgof for multiple hypothesis testing. The principal aim of this package is to implement SGoF-type multiple testing methods, known to be more powerful than the classical false discovery rate (FDR) and family-wise error rate (FWER) based methods in certain situations, particularly when the number of tests is large. This package includes Binomial and...

Charmed meson decays into a pseudoscalar meson P and a tensor meson T are studied. The charm to tensor meson transition form factors are evaluated in the Isgur-Scora-Grinstein-Wise (ISGW) quark model. It is shown that the Cabibbo-allowed decay D+ s → f2(1270)π is dominated by the W -annihilation contribution and has the largest branching ratio in D → TP decays. We argue that the Cabibbo-suppres...

1 Overview The multtest package contains a collection of functions for multiple hypothesis testing. These functions can be used to identify differentially expressed genes in microarray experiments, i.e., genes whose expression levels are associated with a response or covariate of interest. Introduction to multiple testing. This document provides a tutorial for using the multtest package. For a ...

The observables of the GOCE three-axis gradiometer are taken in time, along the orbit and, in the timewise proposal, filtered to stay in the measurement bandwidth, i.e. in the frequency interval between 0.005 and 0.1 Hz. As a consequence, the resulting “observable” is a convolution of the original data stream with a time-wise weighting kernel. In other words, we cannot assume that the observati...

We say that a distribution over {0, 1} is ( , k)-wise independent if its restriction to every k coordinates results in a distribution that is -close to the uniform distribution. A natural question regarding ( , k)-wise independent distributions is how close they are to some k-wise independent distribution. We show that there exists ( , k)-wise independent distribution whose statistical distance...

The microarray gene expression applications have greatly stimulated the statistical research on the massive multiple hypothesis tests problem. There is now a large body of literature in this area and basically five paradigms of massive multiple tests: control of the false discovery rate (FDR), estimation of FDR, significance threshold criteria, control of family-wise error rate (FWER) or genera...

Joshua N. Sampson, Simina M. Boca, Steven C. Moore, and Ruth Heller Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, US, [email protected] Innovation Center for Biomedical Informatics, Georgetown University, Washington, DC, US, [email protected] Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, US, steven.moor...