UNLABELLED This study observed the quantity and functions of wound neu- trophils after topical insulin treatment and investigated the effect of insulin on the wound inflammatory response, as well as the mechanism of insulin-induced wound healing. METHODS Full-thickness excisional wounds were made on the dorsal symmetrical site of C57BL/6J mice. The wounds were treated with either 0.03U insuli...

Penetrating injuries to the duodenum can present a complex case for trauma or acute care surgeons. The associated and complications have devastating results. This report presents of 41-year-old male who presented with gunshot wound his abdomen suffered gastric injury, transverse colon duodenal renal pancreatic tail injury. In this case, patient underwent Roux-en-Y reconstruction. had good outco...

Injury is an inevitable part of life, making wound healing essential for survival. In postembryonic skin, wound closure requires that epidermal cells recognize the presence of a gap and change their behavior to migrate across it. In Drosophila larvae, wound closure requires two signaling pathways [the Jun N-terminal kinase (JNK) pathway and the Pvr receptor tyrosine kinase signaling pathway] an...

Macrophages are present in all tissues, either as resident cells or monocyte-derived cells that infiltrate into tissues. The tissue site largely determines the phenotype of tissue-resident cells, which help to maintain tissue homeostasis and act as sentinels of injury. Both tissue resident and recruited macrophages make a substantial contribution to wound healing following injury. In this revie...

INTRODUCTION Vacuum-assisted wound closure therapy has widely been used in various clinical applications with successful results and has considerably increased in popularity over the past decade. The patient who sustained a complex war wound to his perineum has been presented. METHODS After the initial treatment he was discharged from the hospital in which he had been treated for 4 days in Ir...

Introduction: Trauma is the 3rd major cause of death in urban areas, and cardiac penetrating injury is one of the most important causes of it. Vital signs, mechanism of injury and cardiac tamponad are the important prognostic factors in this patients. At about 70% of alive injured patients have not any clinical symptoms related to cardiac injury, for this reason early diagnosis according to c...

cranial injury, as it is known today, is not a new concern of modern medicine. on stepping on the earth, the man was in reality encountered with various types of injuries, particularly those of a cranial nature. leading a life, whether wild or civilized, has always been associated with injuries for human race from the very beginning of birth. therefore, managing cases of this type has gradually...

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury and repair mechanisms in the CNS. Pharmacological blockade of MMPs, limited to the first several days after spinal cord injury, improves locomotor recovery. This beneficial response is, however, lost when treatment is extended beyond the acutely injured cord to include wound healing and tissue remodeling. ...

Regeneration requires the precise integration of cues that initiate proliferation, direct differentiation, and ultimately re-pattern tissues to the proper size and scale. Yet how these processes are integrated with wounding responses remains relatively unknown. The freshwater planarian, Schmidtea mediterranea, is an ideal model to study the stereotyped proliferative and transcriptional response...