background and objectives: vitamin e is a fat-soluble vitamin with antioxidant properties, which prevents tissue damages induced by free radicals by their neutralization. the aim of this study was to determine the effect of vitamin e on burn wound healing in rats. methods: in this study, 16 mature male rats weighing 260±10g were used in two groups of 8 each. after induction of anesthesia and sh...

objective(s): the aim of the present study was to evaluate the effect of quercus brantii galls extract on the rat skin burn wound healing. materials and methods: ethanol extract of the galls of q. brantii was used to treat the induced burn wounds on the back of 32 wistar rats divided into 4 groups. the groups were treated by placebo, 1%, 2% and 4% concentration gall extract gels for 14 days and...

BACKGROUND Fibromodulin (FMOD) plays a critical role in the wound-healing process. Our previous studies revealed that FMOD deficiency led to marked alterations in adult wound healing characterized by delayed dermal cell migration, postponed wound closure, and increased scar formation, all accompanied by impeded angiogenesis. Therefore, the aim of this study was to reveal the effect of FMOD on a...

Arnebin-1, a naphthoquinone derivative, plays a crucial role in the wound healing properties of Zicao (a traditional wound healing herbal medicine). It has been noted that Arnebin-1, in conjunction with vascular endothelial growth factor (VEGF), exerts a synergistic pro-angiogenic effect on human umbilical vein endothelial cells (HUVECs) and accelerates the healing process of diabetic wounds. H...

OBJECTIVES We have previously shown that stromal cell-derived factor-1α (SDF-1α) is downregulated within diabetic cutaneous wounds, and that direct application of recombinant SDF-1α increases wound closure rates, neovascularization, and endothelial progenitor cell (EPC) recruitment. However, increased wound levels of exogenous SDF-1α results in elevated systemic levels of this proangiogenic che...

objective(s): berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. in this study, we examine...

Abstract In this chapter we present a MATLAB-based computational pipeline for the quantification of monolayer migration assays. Wound healing assay (or scratch assay) is commonly used in vitro to assess collective cell migration. Our outputs traditional and spatiotemporal readouts that quantify group properties was previously screen included thousands time-lapse sequences. You will learn how ex...

BACKGROUND hyaluronan biopolymer is used in dermatology but the underlying mechanism and the impact of its molecular weight have not yet been investigated in skin wound healing. The aim of our work was to study the role of HA molecular weight in the proliferative phase of wound healing and to understand how this physiological biopolymer acts to promote wound healing on a human keratinocyte in v...