Adult progenitor cells proliferate in the acutely injured spinal cord and their progeny differentiate into new oligodendrocytes (OLs) that remyelinate spared axons. Whether this endogenous repair continues beyond the first week postinjury (wpi), however, is unknown. Identifying the duration of this response is essential for guiding therapies targeting improved recovery from spinal cord injury (...

PURPOSE To investigate the integration of subretinal implants containing full-depth perforations of various widths with rat and pig retina across weeks of implantation. METHODS In transgenic P23H rhodopsin line 1 (TgP23H-1) rats and wild-type (WT) pigs, we examined four subretinal implant designs: solid inactive polymer arrays (IPA), IPAs with 5- or 10-μm wide perforations, and active bipolar...

BACKGROUND Previous work demonstrated that a soy-dairy protein blend (PB) prolongs hyperaminoacidemia and muscle protein synthesis in young adults after resistance exercise. OBJECTIVE We investigated the effect of PB in older adults. We hypothesized that PB would prolong hyperaminoacidemia, enhancing mechanistic target of rapamycin complex 1 (mTORC1) signaling and muscle protein anabolism com...

Intraperitoneal injection of virulent infectious pancreatic necrosis virus (IPNV) into yearling brook trout Salvelinus fontinalis induced an asynlptomatic, chronic w u s infection that persisted for at least 76 wk post-lnlection (wpl) in spite of the production of a strong humoral immune response. At 8 wpi, 100 % of the fish in one of the injected groups were IPNV camers , as determined by orga...

Visceral leishmaniasis (VL) is a chronic and fatal disease in humans and dogs caused by the intracellular protozoan parasites, Leishmania donovani and L. infantum (L. chagasi). Relapse of disease is frequent in immunocompromised patients, in which the number of VL cases has been increasing recently. The present study is aimed to improve the understanding of mechanisms of L. donovani persistence...

The incidence of gastric cancer is higher in men than women. Epidemiological studies suggest that female hormones reduce gastric cancer risk. We examined the effect of ovarian-dependent female hormones on Helicobacter pylori-induced gastric cancer in hypergastrinemic INS-GAS mice. Male and female sexually intact or ovariectomized (OVX) mice were inoculated with H.pylori SS1 or vehicle-only at 1...

Abstract Since climate change, intermittent droughts with various severities, poor management and uncontrolled abstraction of water resources, inattention to the balance these resources have caused crisis in recent decades, it is vitally important study scarcity, its changes future, effect change drought on scarcity through appropriate policies agricultural sector. To achieve this goal, present...

Aging populations in developed countries will increase the demand for implantable materials to support tissue regeneration. Whey Protein Isolate (WPI), derived from dairy industry by-products, can be processed into hydrogels with following desirable properties applications engineering: (i) ability adhesion and growth of cells; (ii) ease sterilization by autoclaving (iii) incorporation poorly wa...

The effect of different composite coatings on quality semi-moist apricot cubes mixed with cornflakes was investigated during 180 days storage. were osmotically dehydrated (OD) and coated before hot-air drying (HAD) at 60 °C. Chitosan-bees wax (CBW) whey protein isolate-bees wax-oleic acid (WPI-BW-OA) applied after HAD the samples added to cornflakes. Application OD pectin-ascorbic (Pec-AA) coat...