More than three decades ago allopurinol was considered as a first line drug which regulate uric acid synthesis by inhibiting xanthine oxidase (XO) enzyme. . In addition to allopurinol, febuxostat is also used to reduce the synthesis of uric acid by inhibiting the XO enzyme and is approved by the European Medical Agency in 2008 and US FDA in 2009. . In contrast to allopurinol it acts on both red...

PATIENT Male, 59 FINAL DIAGNOSIS: Xanthogranulomatous osteomyelitis Symptoms: Painful swelling in the wrist Medication: Drug history of antifulgal agents Clinical Procedure: Excisional biopsy Specialty: Radiology. OBJECTIVE Rare disease. BACKGROUND Xanthogranulomatous inflammation is a chronic inflammatory disease in which bone involvement is extremely rare. Bone involvement of xanthogranul...

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the overall importance of radical production in the heart remains conjectural; is it merely a marker of illness, or can intervention alter the progression of disease? This question was addressed by blocking xanthine oxidase (XO), a superoxide-generating enzyme that is upregulated in animal models of hea...

Reactive oxygen species (ROS) are important mediators in vascular biology. Venous function, although relevant to cardiovascular disease, is still understudied. We compared aspects of ROS metabolism between a major artery (the aorta) and a major vein (the vena cava, VC) of the rat, with the hypothesis that venous ROS metabolism would be overall increased compared with its arterial counterpart. S...

L-amino acid oxidase (LAAO) has important biological roles in many organisms, thus attracting great attention from researchers to establish its detection methods. In this study, a new quantitative in-gel determination of LAAO activity based on ferric-xylenol orange (Fe(III)XO) formation was established. This method showed that due to the conversion of Fe(II) to Fe(III) by H2O2 and subsequent fo...

In spite of over 40 years of clinical use of 6-mercaptopurine, many aspects of complex pharmacology and metabolism of this drug remain unclear. It is thought that 6-mercaptopurine is oxidized to 6-thiouric acid through 6-thioxanthine or 8-oxo-6-mercaptopurine by one of two molybdenum hydroxylases, xanthine oxidase (XO), however, the role of other molybdenum hydroxylase, aldehyde oxidase (AO), i...

The contribution of toxic O2 metabolites to cerebral ischemia reperfusion injury has not been determined. We found that gerbils subjected to temporary unilateral carotid artery occlusion (ischemia) consistently developed neurologic deficits during ischemia with severities that correlated with increasing degrees of brain edema and brain H2O2 levels after reperfusion. In contrast, gerbils treated...

BACKGROUND Dilated cardiomyopathy is characterized by an imbalance between left ventricular performance and myocardial energy consumption. Experimental models suggest that oxidative stress resulting from increased xanthine oxidase (XO) activity contributes to this imbalance. Accordingly, we hypothesized that XO inhibition with intracoronary allopurinol improves left ventricular efficiency in pa...

Consider a finite number of variables Xn, n ∈ N, in the respective finite sets Xn. For R ⊆ N, we denote by XR the tuple of variables that takes values in the Cartesian product XR := ×r∈RXr. We denote by G (XR) the set of gambles on XR. Suppose DN ⊆ G (XN) models a subject’s beliefs about XN, Marginalisation. The corresponding beliefs about the variable XO, where O⊆ N, are given by the marginal ...

are the Lebesgue functions and Lebesgue constants of the interpolation, respectively . We now prove this statement in full detail . The detailed proof turned out to be quite complicated and several unsuspected difficulties had to be overcome . In the same paper P. Erdős also stated, that there is a pointgroup {x kn } so that for every continuous f (x) (-1 x:1) L,,(f, x,) -f (xo) holds for at le...