Recently, Gentile et a l l reported what they believe to be a new disease, ie, CD3+, CD56' aggressive variant of large granular lymphocyte (LGL) leukemia. At presentation or during the course of the disease, all 3 patients were reported to have an absolute lymphocytosis, a moderate degree of thrombocytopenia, and massive splenomegaly, Splenectomy specimens in all 3 cases showed preferential inv...

Recently, Gentile et a l l reported what they believe to be a new disease, ie, CD3+, CD56' aggressive variant of large granular lymphocyte (LGL) leukemia. At presentation or during the course of the disease, all 3 patients were reported to have an absolute lymphocytosis, a moderate degree of thrombocytopenia, and massive splenomegaly, Splenectomy specimens in all 3 cases showed preferential inv...

to d ia ic st s, e as w n us of y ic id e ry yAbstract: Molecular epidemiology is the study of genetic and enviro mental risk for disease, with much effort centered on cancer. Childhoo leukemia occurs in nearly a third of all patients newly diagnosed with p diatric cancer. Only a small percentage of these new cases of childhood le kemia are associated with high penetrant hereditary cancer syndr...

Citation: Kato H, Kawase T, Kako S, Mizuta S, Kurokawa M, Mori T, Ohashi K, Iwato K, Miyamura K, Hidaka M, Sakamaki H, Suzuki R, Morishima Y, and Tanaka J. Analysis of outcomes following autologous stem-cell transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia during the first complete remission. Haematologica. 2014; 99:xxx doi:10.3324/haematol.20...

Introduction . Identical twins are a unique model that can be used to assess the concordance of various diseases, including acute leukemia. It should noted leukemia is characterized with high in cases monovular or placentas adhesion, which confirms development this disease prenatal period. Aim — present clinical case successful diagnosis and treatment lymphoblastic identical twins. Main finding...

Abstract Leukemia is a malignancy that affects the blood and bone marrow. Its detection classification are conventionally done through labor-intensive specialized methods. The diagnosis of cancer in children critical task requires high precision accuracy. This study proposes novel approach utilizing attention mechanism-based machine learning conjunction with image processing techniques for prec...

abstract the antineoplastic activities of alcoholic and aqueous extracts of the roots, stems and leaves of isatis campylocarpa an endemic species of the brassicaceae family from iran, investigated on the growth of jurkat as an acute lymphocytic leukemia cell line, k562 as a chronic myelogenous leukemia cell line and fen as a bladder cancer cell line using colorimetric assay. results showed that...

Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived MSCs could inhibit Jurkat lym-phoblastic leukemia T cell proliferation during coculture. Me...

PURPOSE Donor T cells respond to minor histocompatibility antigens (mHA), resulting in both graft-versus-host disease and graft versus leukemia after allogeneic hematopoietic stem cell transplantation. Because relatively few mHAs are known, we developed a new approach to predict and subsequently validate candidate mHA. EXPERIMENTAL DESIGN We developed an algorithm based on genetic disparities...