ZEB, an E-box binding transcriptional repressor, is an important regulator of T cell and muscle development. Targeted disruption of ZEB in mice resulted in a strong reduction of thymocytes and the few T cells that reached the mature stage were predominantly CD4(+). CD4 expression during the various stages of T cell differentiation is controlled at the transcriptional level by a complex array of...

The concept of Design-Build-Operate Energy Information Modeling (DBO-EIM) is proposed. The DBO-EIM aims at creating a detailed and persistent energy model that can be used to reduce energy consumption and improveoccupant comfort throughout the life-cycle of a building. Within the framework, the model is builtto supportdecision makingin the design phase, validated and tuned during construction a...

Epigenetic alterations such as histone acetylation and DNA methylation play an important role in the regulation of gene expression for cell cycles and apoptosis that may affect the chemosensitivity of cancers. Previously, we have reported that the combination of suberoylanilide hydroxamic acid (SAHA), a newly developed histone deacetylase inhibitor, with cisplatin (CDDP) possessed synergistic c...

The objective of this study is to derive a design methodology for zero-energy building considering the energy production and consumption building. In order establish methodology, various factors affecting are derived, effect heat transmission rate, surface volume ratio (S/V ratio), location orientation analyzed by simulation method. As result, S/V rate most important in central region Korea whe...