The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

Much of enzyme kinetics builds on simplifications enabled by the quasi-steady-state approximation and is highly useful when the concentration of the enzyme is much lower than that of its substrate. However, in vivo, this condition is often violated. In the present study, we show that, under conditions of realistic yet high enzyme concentrations, the quasi-steady-state approximation may readily ...

This article outlines the principles ofdrug elimination, principally by the liver and kidneys. Most elimination processes of drugs follow first-order elimination kinetics. In such processes a defined and constant fraction of a drug-for example, half-is irreversibly eliminated in a constant time. The half-life time (t1) in such first-order processes is the time taken for the concentration of the...

The rate at which tomato fruits ripe was investigated via the biosynthesis of lycopene in two tomato varieties under the conditions of field and ambient temperature ripening. Results showed that the biosynthesis of lycopene follows a first-order kinetics in both varieties with calculated rate constants of 1.2×10-2 and 1.4×10-2 d-1 for Ibadan local and Roma types respectively under the field rip...

The kinetics of N2O decomposition to gaseous nitrogen and oxygen over HZSM-5 catalysts with low content of iron (<400 ppm) under transient and steady-state conditions was investigated in the temperature range of 250–380 8C. The catalysts were prepared from the HZSM-5 with Fe in the framework upon steaming at 550 8C followed by thermal activation in He at 1050 8C. The N2O decomposition began at ...

Drug release kinetics plays an important role in determining the mechanism of drug release, which in turn helps in formulating controlled/sustained release formulations.In our study, different concentrations of green tea polyphenols (GTP) were encapsulated into casein nanoparticles which showed a maximum encapsulation efficiency (76.9%) at a GTP concentration of 5 mg/mL. The casein nanopa...

Drug release kinetics plays an important role in determining the mechanism of drug release, which in turn helps in formulating controlled/sustained release formulations.In our study, different concentrations of green tea polyphenols (GTP) were encapsulated into casein nanoparticles which showed a maximum encapsulation efficiency (76.9%) at a GTP concentration of 5 mg/mL. The casein nanopa...