Synthesis and spectral evaluation of new zinc and copper unsymmetrical mesoporphyrinic complexes are reported. Zn(II)-5-(4-acetoxy-3-methoxyphenyl)-10,15,20- tris-(4-carboxymethylphenyl)porphyrin, Zn(II)-5-[(3,4-methylenedioxy)phenyl]-10,15,20- tris-(4-carboxymethylphenyl)porphyrin, Cu(II)-5-(4-acetoxy-3-methoxyphenyl)-10,15,20- tris-(4-carboxymethylphenyl)porphyrin and Cu(II)-5-[(3,4-methylene...

The synthesis and characterisation of low-coordinate zinc and cadmium complexes of the sterically demanding 1,3,6,8-tetra-tert-butylcarbazol-9-yl ligand ((t)Bu(4)carb(-)) are reported. ((t)Bu(4)carb)(2)M (M = Zn 1; M = Cd 2) are the first examples of formally two-coordinate bis-carbazol-9-yl complexes of the Group 12 metals and 2 is the first crystallographically characterised two-coordinate am...

In this paper we use mono- and bi-metallic complexes, based on earth-abundant, cheap benign zinc, for the synthesis of sustainable aliphatic semi-aromatic polyesters. Tridentate hexadentate aldimine-thioetherphenolate ligands...

Zinc is abundant in the brain, where it plays an important role in synaptic plasticity and in learning; however, excessive zinc is toxic to neuronal cells, and dyshomeostasis of zinc in the brain is a contributing factor for Alzheimer's disease (AD). Deposition of zinc has been detected in senile plaques in the form of zinc-Aβ (β-amyloid) complexes. Recent studies have demonstrated that zinc ex...

Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes enable these metal-based drugs to reach biological targets. Palladium(II) gold(III) complexes, due its structural similarity platinum(II)compounds, be competitive candidates for implementing developing new pharmacological agents. Herein, novel complex triammoniu...

macrocyclic heterobinuclear zn(ii)–cu(ii) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. the ligands include similar n4o2 and dissimilar n(imine)3o2 and n(amine)3o2 coordination sites sharing two phenolic oxygen atoms. the six-coordination site comprises two pyridyl pendant arms on the amine nit...

The zinc complexes [(L1)(2)Zn(MeOH)(2)](OTf)(2), [(L1)ZnCl(2)], [(L2)ZnCl(2)], [(L2)Zn(OTf)(H(2)O)]OTf and [(Me-bispic)ZnCl(2)] of the ligands N-[(2-pyridyl)methyl]-2,2'-dipyridylamine (L1), N-[bis(2-pyridyl)methyl]-2-pyridylamine (L2) and N-methyl-[bis(2-pyridyl)methyl]amine (Me-bispic) were synthesised and characterised. The first copper(I) complexes of the ligands L1 and L2 were also synthes...

The synthesis and characterization of biotinylated chlorin photosensitizer and the corresponding zinc and indium complexes are described for potential applications in photodynamic therapy (PDT) for cancer. Phototoxicity of the biotin-chlorin conjugate and the metallated complexes was determined in colon carcinoma CT26 cell lines known to overexpress biotin (Vit B₇) receptors. Cell survival assa...

The ability of hesperidin (HP) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. The complexation was studied using U.V spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). Potential complexes were studied by IR and NMR spectroscopy, melting point and their solubility were also evaluated. The interac...