Dysregulation of neuronal zinc homeostasis plays a major role in many processes related to brain aging and neurodegenerative diseases, including Alzheimer's disease (AD). Yet, despite the critical role of zinc in neuronal function, the cellular mechanisms underpinning its homeostatic control are far from clear. We reported that the cellular prion protein (PrP(C)) is involved in the uptake of zi...

a thermodynamic study on the interaction between zinc ion (zn2+) and human growth hormone(hgh) was studied at two temperatures of 27c and 37c in aqueous solution using an isothermal titrationcalorimetry. it was found that there is a set of three identical and non-interacting binding sites for zn2+ ions. the intrinsic dissociation equilibrium constant and the molar enthalpy of binding are 1.54...

Zn-Al layered double hydroxide (LDH) nanoparticles with carbonate as the charge balancing anion in the interlayer space were synthesized using co-precipitation method. Then, the carbonate base Zn-Al LDH nanoparticles were doped with phosphate ion via anion-exchange reaction to synthesize Zn-Al-[PO43-]-[CO32-]. The structure and composition were characterized by X-ray diffraction (XRD), Fourier ...

Selective detection of Sm 3+ ion at a very low concentration is achieved using tetra-coordinated boron appended Zinc(salen).

A fluorescent supramolecular polymer was efficiently constructed by pillar[5]arene-based host-guest molecular recognition and zinc ion coordination.

We present a mobile trap algorithm to sense zinc ions using protein-based sensors such as carbonic anhydrase (CA). Zinc is an essential biometal required for mammalian cellular functions although its intracellular concentration is reported to be very low. Protein-based sensors like CA molecules are employed to sense rare species like zinc ions. In this study, the zinc ions are mobile targets, w...

The title compound, [Zn(C(2)N(3))(2)(C(12)H(9)NO)(2)](n), is a polymeric zinc(II) complex with the metal ion located on an inversion centre. The Zn(II) ion is six-coordinated by two N atoms of two 3-benzoyl-pyridine ligands and four N atoms from four dicyanamide ligands, forming a slightly distorted octa-hedral configuration. In the crystal structure, neighboring Zn atoms are linked together by...

Zinc ion-induced pyrrole hydrogen ionization from a histidyl residue has recently been suggested as the source of the activity-related deprotonation in carbonic anhydrase (EC 4.2.1.1; carbonate hydro-lyase) occurring at pH 7-8. The results offered to support the hypothesis are shown to be deficient. Examination of the literature reveals no precedent for such a pronounced acidification from pK(a...