A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of [6], [8] and [10]-gingerols and [6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 x higher than that of ty...

Reactive oxygen species [ROS] cause oxidative damage to the tissues and protection from such damages are provided by endogenous and exogenous antioxidants. Plant based antioxidants are preferred due to the multiple mechanisms of actions and of the phytochemicals present in them. 80% alcoholic extract of leaves of Aloe vera, Bacopa monniera, Moringa oleifera and rhizome of Zingiber officinale wa...

Antimicrobial properties of phytochemicals extracted from onion (Allium cepa) and ginger (Zingiber officinale) were evaluated against Escherichia coli and Staphylococcus aureus, two common food borne pathogens. They were tested using minimum inhibitory concentration, minimum bactericidal concentration disc diffusion and agar wells diffusion. Onion showed good antimicrobial properties against S....

The antibacterial and anti-biofilm activity of ethanolic extract from the rhizome of Zingiber officinale were evaluated. In vitro antibacterial activity was investigated by microdilution method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined. The values were in the range from 0.0024 to > 20 mg/ml. The most sensitive bacteria were Gram-po...

The current aim of our research work is to isolate bio-polymer from fresh rhizomes of Zingiber officinale & to evaluate its retardibility by formulating microdwarfs containing nimesulide as a model drug. The bio-material was isolated by a simplified method. Six different bio-micro dwarf formulations were prepared using isolated bio-material as a retardant. The formulated microcapsules were eval...

The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. A...

Eight commonly used spices Syzygium aromaticum, Cinnamonum zeylanicum, Zingiber officinale, Murraya koenigii, Piper nigrum, Trachyspermum ammi, Allium sativum and Allium cepa were tested for in vitro antifungal activity on Aspergillus niger, a causative agent of different destructive disease. Out of eight plant materials used, five showed significant antifungal activity against the test pathoge...

Zingiber officinale (ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data from in vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, an...

The study investigates the phytochemistry, Gas-Chromatography–Mass Spectrometry (GC-MS), atomic Absorbtion spectroscopy (AAS) and antidiabetic activities of aqueous ginger (Zingiber officinale) extract in diabetic alloxan-induced Wistar rats. Qualitative phytochemical analysis, GC-MS, AAS properties were determined using standard procedures. Phytochemical analysis shows that contains tannins, f...

In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol. Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol and [6...