homoalcophosphamide by the procedure of Corey and Kim (7) gave diethylaldophosphamide and diethylhomoaldophos phamide, respectively (Chart 2). Diethylaldophosphamide was characterized by mass spectral analysis [m/e 283, 1 Cl, M2— CH2C1@; m/e 192, no Cl, M —N(CH2CH2C1)2] and by positive qualitative tests as an aldehyde and an alkylating agent. Complete purification of diethylaldophosphamide ...

In an attempt to better understand breast tumors sensitivity or resis tance to anticancer drugs, the main drug-metabolizing enzyme systems were evaluated in both breast tumors and their corresponding peritumoral tissues in 12 patients. The following enzymes were assayed by Western blot: cytochromes P-4SO (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4); glutathione .S'-transferases (GST-a, -u, and -TI); and ...

The in vivo fate of various “In-labeled polypeptides has been the subject of many investigations. Intracellular metabolism has been StUdied through the use of “In-labeled glycoproteins that are concentrated in the lysosome by receptor-mediated endocytosis. These studies have Indicated that the main lysosomal metabolite is “In-chelate-e-lysine, both in vitro and in vivo (Y. Arano et aL, J....

Aims—To investigate whether anomalies of transforming growth factor â type II receptor (TGF-â RII) expression occur in the early stages of laryngeal carcinogenesis and to assess their importance in the development of laryngeal squamous cell carcinoma. TGF-â RII status was examined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of similar les...

C —¿ > T transitions at CpG sites are the most prevalent mutations found in the p53 tumor suppressor gene in human colon tumors and in the germline (Li-Fraumeni syndrome). All of the mutational hot spots are methylated to 5-methylcytosine, and it has been hypothesized that the majority of these mutations are caused by spontaneous hydrolytic deamination of this base to thymine. We have previou...

Cocoa butter was crystallized statically from the melt to various temperatures in the range of -20 to 26 °C and annealed for up to 45 days. During this period, the polymorphism of the solid state was monitored using differential scanning calorimetry and powder X-ray diffraction. Moreover, the microstructure of the materials was imaged using polarized light microscopy. Below -15 °C, a mixture of...

ofthe various factors that go into the computation better; it also segregates the least reliable and error-prone model-dependent components into terms that can be identified and minimized. Regional cerebral glucose utilization is calcu lated as: IT C@†• (T) †" K'I' I C@(t) e@ +k@)(Tt) dt JO (IfTC(t) fTC@(t) e@ +k@)(Tt) dt)-@-dt-i; 0 @ 0 Eq.! where C@' represents total concentration of ‘4C...