t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

background: microtubules (mt) are important components of cell cytoskeleton and play key roles in cell motility mitosis and meiosis. they are also the targets of several anticancer agents which indicating their importance in maintaining cell viability. microtubular reorganization contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic...

Fibrinogen γ' (γ') is a natural isoform of fibrinogen, and alters the rate of formation and the properties of clots. It could therefore affect outcome after ischaemic stroke. The prognostic significance of γ' fibrinogen levels is, however, still unclear. It was the objective of this study to assess levels of γ' in ischaemic stroke, and its association with short-term outcome. We included 200 is...

BACKGROUND Phosphorylated histone H2AX ( γ -H2AX) is a potential regulator of DNA repair and is a useful tool for detecting DNA damage. To evaluate the clinical usefulness of γ -H2AX in hepatocellular carcinoma (HCC), we measured the level of γ -H2AX in HCC, dysplastic nodule, and nontumorous liver diseases. METHODS The level of γ -H2AX was measured by immunohistochemistry in fifty-eight HCC,...

Hypoxia enhances transforming growth factor-β (TGF-β) signaling, inhibiting alveolar development and causing abnormal pulmonary arterial remodeling in the newborn lung. We hypothesized that, during chronic hypoxia, reduced peroxisome proliferator-activated receptor-γ (PPAR-γ) signaling may contribute to, or be caused by, excessive TGF-β signaling. To determine whether PPAR-γ was reduced during ...

We consider systems of n parallel edge dislocations in a single slip system, represented by points in a two-dimensional domain; the elastic medium is modelled as a continuum. We formulate the energy of this system in terms of the empirical measure of the dislocations, and prove several convergence results in the limit n → ∞. The main aim of the paper is to study the convergence of the evolution...

In this paper, the equilibrium behavior of an immiscible two phase fluid on a rough surface is studied from a phase field equation derived from minimizing the total free energy of the system. When the size of the roughness becomes small, we derive the effective boundary condition for the equation by the multiple scale expansion homogenization technique. The Wenzel and Cassie equations for the a...

A 3D-2D dimensional reduction analysis for supremal functionals is performed in the realm of Γ-convergence. We show that the limit functional still admits a supremal representation, and we provide a precise identification of its density in some particular cases. Our results rely on an abstract representation theorem for the Γ-limit of a family of supremal functionals. Mathematics Subject Classi...

This paper deals with the passage from discrete to continuous in modeling the static elastic properties, in the setting of anti-planar linear elasticity, of vertical screw dislocations in a cylindrical crystal. We study, in the framework of Γ-convergence, the asymptotic behavior of the elastic stored energy induced by dislocations as the atomic scale ε tends to zero, in the regime of dilute dis...

We deal with a class of reaction-diffusion equations, in space dimension d > 1, perturbed by a Gaussian noise ∂wδ/∂t which is white in time and colored in space. We assume that the noise has a small correlation radius δ, so that it converges to the white noise ∂w/∂t, as δ ↓ 0. By using arguments of Γ-convergence, we prove that, under suitable assumptions, the quasi-potential Vδ converges to the...